Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL224165 | 0.96 | ALDH1A1 (0.71) | ALDH1A1GAAKDM4EPOLBMAPT | |
| Hydrochloric Acid SCHEMBL7410231 | 0.95 | ALDH1A1 (0.69) | ALDH1A1GAAKDM4EPOLBMAPT | |
| SCHEMBL31321291 | 0.87 | GAA (0.58) | ALDH1A1GAAKDM4EPOLBMAPT | |
| SCHEMBL1761307 | 0.83 | ALDH1A1 (0.54) | ALDH1A1GAAKDM4EPOLBMAPT | |
| SCHEMBL570110 | 0.82 | GAA (0.61) | ALDH1A1GAAKDM4EPOLBMAPT | |
| SCHEMBL8000660 | 0.82 | ALDH1A1 (0.76) | ALDH1A1GAAKDM4EMAPTHSD17B10 | |
| SCHEMBL15055753 | 0.81 | GAA (0.60) | ALDH1A1GAAKDM4EPOLBMAPT | |
| Hydrochloric Acid SCHEMBL15488205 | 0.81 | GAA (0.59) | ALDH1A1GAAKDM4EPOLBMAPT | |
| Hydrochloric Acid SCHEMBL7564049 | 0.81 | GAA (0.59) | ALDH1A1GAAKDM4EPOLBMAPT | |
| SCHEMBL1354320 | 0.80 | ALDH1A1 (0.73) | ALDH1A1GAAKDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456267-A | A method of synthesis pleasure is cut down for Buddhist nun | 南京天越星生物技术有限公司 | 2019-03-12 | — | — | CN | disclosed |