SCHEMBL28877271

SCHEMBL28877271

Fc1c(F)c(F)c2c(-c3ccc(C(F)(F)F)cc3C(F)(F)F)nnc(-c3ccccc3)c2c1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.42
ADORA1 P30542 2/20 0.42
ABCC8 Q09428 1/20 0.38
KCNJ11 Q14654 1/20 0.38
MAOB P27338 2/20 0.38
ALOX5AP P20292 1/20 0.38
FEN1 P39748 1/20 0.38
KIF11 P52732 1/20 0.38
EDNRB P24530 1/20 0.36
EDNRA P25101 1/20 0.36
NPBWR1 P48145 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
GAA P10253 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CYP2C9 P11712 1/20 0.35
SCN9A Q15858 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
DHODH Q02127 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29947822 0.90 ABCC8 (0.44) ABCC8KCNJ11MAOBALOX5APFEN1
SCHEMBL29947909 0.80 MAT2A (0.37) ALOX5APFEN1KIF11EDNRBEDNRA
SCHEMBL28877250 0.80 MAT2A (0.37) ALOX5APFEN1KIF11EDNRBEDNRA
SCHEMBL28877253 0.80 KDM4E (0.38) ABCC8KCNJ11ALOX5APFEN1TDP1
SCHEMBL28877261 0.78 PDE3B (0.40) ADORA2AADORA1ABCC8KCNJ11ALOX5AP
SCHEMBL28465389 0.78 ADORA2A (0.45) ADORA2AADORA1ABCC8KCNJ11MAOB
SCHEMBL28877259 0.78 MPL (0.34) ABCC8KCNJ11ALOX5APFEN1KCNH2
SCHEMBL4781603 0.76 KIF11 (0.54) ALOX5APFEN1KIF11EDNRBEDNRA
SCHEMBL29947885 0.76 MKNK1 (0.47) MAOBKIF11NPSR1MEN1KMT2A
SCHEMBL28877316 0.75 ADORA2A (0.43) ADORA2AADORA1GAANPSR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115260245-A Iridium metal complex, application thereof and organic electroluminescent device 清华大学 2022-11-01 CN disclosed