Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11356136 | 0.94 | HSP90AA1 (0.77) | HSP90AA1LMNATSHRPDE7AALDH1A1 | |
| SCHEMBL31405188 | 0.94 | HSP90AA1 (0.77) | HSP90AA1LMNATSHRPDE7AALDH1A1 | |
| SCHEMBL20591230 | 0.86 | HSP90AA1 (0.61) | HSP90AA1LMNATSHRPDE7AALDH1A1 | |
| SCHEMBL18550254 | 0.86 | HSP90AA1 (0.61) | HSP90AA1LMNATSHRPDE7AALDH1A1 | |
| SCHEMBL10650255 | 0.85 | TP53 (0.61) | HSP90AA1LMNATSHRPDE7AALDH1A1 | |
| SCHEMBL4801505 | 0.84 | TSHR (0.70) | HSP90AA1LMNATSHRPDE7AALDH1A1 | |
| SCHEMBL11635203 | 0.82 | HSP90AA1 (0.56) | HSP90AA1LMNATSHRPDE7AALDH1A1 | |
| SCHEMBL11662774 | 0.82 | NFE2L2 (0.57) | HSP90AA1LMNATSHRALDH1A1NFE2L2 | |
| SCHEMBL288227 | 0.82 | HSP90AA1 (1.00) | HSP90AA1LMNATSHRALDH1A1NFE2L2 | |
| SCHEMBL20347051 | 0.82 | HSP90AA1 (0.77) | HSP90AA1LMNATSHRALDH1A1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396316-B1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-01 | — | — | EP | disclosed |
| US-8937078-B2 | Quinazolinones as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-20 | — | — | US | disclosed |
| EP-2396316-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010093727-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-19 | — | — | WO | disclosed |
| US-20100204226-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-12 | — | — | US | disclosed |
| US-7683218-B2 | Method for producing thioether compound | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-03-23 | — | — | US | disclosed |
| US-7683218-B2 | Method for producing thioether compound | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-03-23 | — | — | US | disclosed |
| US-7683218-B2 | Method for producing thioether compound | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-03-23 | — | — | US | disclosed |
| US-20080108823-A1 | Method For Producing Thioether Compound | MSD K.K. (JP) | 2008-05-08 | — | — | US | disclosed |
| US-20080108823-A1 | Method For Producing Thioether Compound | MSD K.K. (JP) | 2008-05-08 | — | — | US | disclosed |
| US-20080108823-A1 | Method For Producing Thioether Compound | MSD K.K. (JP) | 2008-05-08 | — | — | US | disclosed |
| EP-1806337-A1 | METHOD FOR PRODUCING THIOETHER COMPOUND | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1806337-A1 | METHOD FOR PRODUCING THIOETHER COMPOUND | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-07-11 | — | — | EP | disclosed |
| US-4238619-A | Method for making aryl onium salts of group via elements | GENERAL ELECTRIC COMPANY (US) | 1980-12-09 | — | — | US | disclosed |
| US-4164412-A | HERBICIDES, ANTIINFLAMMATORY, ANALGESIC | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1979-08-14 | — | — | US | disclosed |
| US-4086255-A | HERBICIDES, ANTIINFLAMMATORY AGENTS, ANALGESIC AGENTS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1978-04-25 | — | — | US | disclosed |
| US-4005141-A | HERBICIDES, ANTIINFLAMMATORY AGENTS, ANALGESICS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1977-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204226-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | P4HA1, EGLN3, EGLN2 | HSP90AA1 555/4885LMNA 2710/4885TSHR 3968/4885 |
| US-20080108823-A1 | Method For Producing Thioether Compound | TST, MPST, PPIP5K2 | HSP90AA1 3827/4885LMNA 4839/4885TSHR 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.