Sugi Predict

Sugi Predict / Compounds / SCHEMBL2897323

SCHEMBL2897323

SCHEMBL2897323

Nc1cc(-c2ccccc2)cs1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.45
▸ MEN1 O00255 4/20 0.45
▸ KMT2A Q03164 4/20 0.45
▸ LMNA P02545 3/20 0.45
▸ NPC1 O15118 3/20 0.45
▸ RAB9A P51151 3/20 0.45
▸ KDM4E B2RXH2 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ NFKB1 P19838 1/20 0.45
▸ NFKB2 Q00653 1/20 0.45
▸ RELA Q04206 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ MAOA P21397 1/20 0.44
▸ CYP3A4 P08684 2/20 0.44
▸ HSD17B10 Q99714 2/20 0.44
▸ TAAR1 Q96RJ0 1/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44
▸ HDAC6 Q9UBN7 1/20 0.43
▸ CYP2E1 P05181 1/20 0.39
▸ CYP2A6 P11509 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL15910915 0.98 ALDH1A1 (0.44) ALDH1A1MEN1KMT2ALMNANPC1
SCHEMBL3258545 0.79 MAPT (0.50) ALDH1A1MEN1KMT2ALMNANPC1
SCHEMBL12465845 0.77 ALAD (0.52) ALDH1A1MEN1KMT2ALMNANPC1
SCHEMBL12466215 0.77 ALDH1A1 (0.47) ALDH1A1MEN1KMT2ARAB9AKDM4E
SCHEMBL28053640 0.77 ALDH1A1 (0.40) ALDH1A1MEN1KMT2ALMNANPC1
SCHEMBL23539914 0.77 TAAR1 (0.47) ALDH1A1TAAR1MAP4K4
SCHEMBL12960188 0.77 HSD17B10 (0.47) ALDH1A1MEN1KMT2ANPC1RAB9A
SCHEMBL7221096 0.77 HSD17B1 (0.38) ALDH1A1MEN1KMT2ARAB9AKDM4E
SCHEMBL7028507 0.77 ALDH1A1 (0.56) ALDH1A1MEN1KMT2ALMNANPC1
SCHEMBL5695918 0.76 ALDH1A1 (0.43) ALDH1A1MEN1KMT2ALMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0661289-B1 Vinyl carboxamide derivatives as insecticides and acaricides SYNGENTA PARTICIPATIONS AG (CH) 2004-03-03 — — EP claimed
US-12559495-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2026-02-24 — — US disclosed
CN-115466229-B Para-amidobenzenesulfonyl compound and application thereof 上海中医药大学 2025-01-24 — — CN disclosed
EP-4389738-A1 SOS1 INHIBITOR AND USE THEREOF Kanaph Therapeutics Inc. (KR) 2024-06-26 — — EP disclosed
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-06-08 — — US disclosed
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-06-08 — — US disclosed
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-06-08 — — US disclosed
US-11555037-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-01-17 — — US disclosed
CN-115466229-A P-acylamino benzenesulfonyl compound and application thereof 上海中医药大学 2022-12-13 — — CN disclosed
CN-109776537-B Purine diones as WNT pathway modulators 新加坡科技研究局 2021-12-14 — — CN disclosed
US-20100041695-A1 Thieno[2,3-b]pyridines as Potassium Channel Inhibitors XENTION LIMITED (GB) 2010-02-18 — — US disclosed
US-7576212-B2 Thieno[2,3-B] pyridines as potassium channel inhibitors XENTION LIMITED (GB) 2009-08-18 — — US disclosed
EP-1879899-A1 THIENOPYRIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS Xention Discovery Limited (GB) 2008-01-23 — — EP disclosed
US-20060183768-A1 Compounds XENTION DISCOVERY LTD. (GB) 2006-08-17 — — US disclosed
WO-2006061642-A1 COMPOUNDS XENTION DISCOVERY LIMITED (GB) 2006-06-15 — — WO disclosed
EP-0207345-B1 4,7-Dihydrothieno[2,3-b]pyridine derivatives, process thereof, and agents for cardiovascular diseases SHIONOGI & CO., LTD. (JP) 1992-01-22 — — EP disclosed
US-4703051-A CALCIUM CHANNEL BLOCKERS; HYPOTENSIVES, VASODILATORS SHIONOGI & CO., LTD. (JP) 1987-10-27 — — US disclosed
EP-0207345-A2 4,7-Dihydrothieno[2,3-b]pyridine derivatives, process thereof, and agents for cardiovascular diseases SHIONOGI & CO., LTD. (JP) 1987-01-07 — — EP disclosed
US-4263205-A FOR COLORING POLYMERS, LACQUERS CIBA-GEIGY CORPORATION (US) 1981-04-21 — — US disclosed
EP-0006154-A1 Monoazo pigments and their use in colouring high molecular-weight organic material CIBA-GEIGY AG (CH) 1980-01-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041695-A1 Thieno[2,3-b]pyridines as Potassium Channel Inhibitors SCN8A, SCN1B, SCN2B ALDH1A1 3155/4885MEN1 4162/4885KMT2A 2561/4885
US-11555037-B2 Purine diones as Wnt pathway modulators WNT1, WNT3A, WNT3 ALDH1A1 1754/4885MEN1 4612/4885KMT2A 3027/4885
US-20060183768-A1 Compounds SCN7A, CBR3, SCN8A ALDH1A1 2799/4885MEN1 4387/4885KMT2A 3452/4885
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS WNT1, WNT3A, WNT3 ALDH1A1 1754/4885MEN1 4612/4885KMT2A 3027/4885
US-12559495-B2 Purine diones as Wnt pathway modulators WNT1, CTNND1, WNT3A ALDH1A1 1125/4885MEN1 3612/4885KMT2A 2932/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.