Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 7/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29062403 | 0.85 | KMO (0.59) | KMOMAP4K4MINK1TNIKIDO1 | |
| Potassium Ion SCHEMBL29020126 | 0.81 | KMO (0.50) | KMOADORA2A | |
| Potassium Ion SCHEMBL28802979 | 0.77 | KMO (0.51) | KMO | |
| Potassium Ion SCHEMBL29020190 | 0.74 | KMO (0.46) | KMO | |
| SCHEMBL823967 | 0.73 | MAP4K4 (0.51) | KMOMAP4K4MINK1TNIKIDO1 | |
| Potassium Ion SCHEMBL29020215 | 0.71 | KMO (0.46) | KMO | |
| Potassium Ion SCHEMBL29020198 | 0.71 | DHODH (0.50) | KMO | |
| SCHEMBL29961689 | 0.68 | KMO (0.51) | KMOMAP4K4 | |
| SCHEMBL29020201 | 0.68 | KMO (0.51) | KMOMAP4K4 | |
| Potassium Ion SCHEMBL30569988 | 0.68 | S1PR2 (0.43) | KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115093400-B | AhR inhibitor, application and preparation method thereof | 北京华森英诺生物科技有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-115093400-A | AhR inhibitor and application and preparation method thereof | 重庆华森制药股份有限公司 | 2022-09-23 | — | — | CN | disclosed |