Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333594 | 0.96 | CTSD (0.56) | CTSDSTAT3HTTNPC1RAB9A | |
| SCHEMBL2514158 | 0.96 | CTSD (0.56) | CTSDSTAT3HTTNPC1RAB9A | |
| Zinc Ion SCHEMBL10404876 | 0.96 | CTSD (0.56) | CTSDSTAT3HTTNPC1RAB9A | |
| Lithium Ion SCHEMBL7961800 | 0.96 | CTSD (0.56) | CTSDSTAT3HTTNPC1RAB9A | |
| SCHEMBL10977449 | 0.89 | HPGD (0.50) | CTSDSTAT3HTTNPC1RAB9A | |
| SCHEMBL9149713 | 0.86 | NPC1 (0.47) | CTSDSTAT3HTTNPC1RAB9A | |
| Potassium Ion SCHEMBL29619648 | 0.84 | KDM4E (0.44) | CTSDSTAT3HTTNPC1RAB9A | |
| Potassium Ion SCHEMBL1002905 | 0.84 | KDM4E (0.44) | CTSDSTAT3HTTNPC1RAB9A | |
| P-Anisic Acid SCHEMBL28313272 | 0.84 | CA1 (0.59) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| Potassium Ion SCHEMBL1002904 | 0.82 | KDM4E (0.53) | CTSDHTTNPC1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116354924-B | 2-Imidazolone derivative and application thereof | 江苏恩华药业股份有限公司 | 2025-05-30 | — | — | CN | disclosed |
| CN-116354924-A | 2-imidazolone derivative and application thereof | 江苏恩华药业股份有限公司 | 2023-06-30 | — | — | CN | disclosed |