SCHEMBL2909138

SCHEMBL2909138

COc1ccc(S(=O)(=O)Nc2c(C)c(C)c3c(c2C)C(c2ccc(C(C)C)cc2)C(C)(C)O3)cc1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 7/20 0.40
HSD17B10 Q99714 3/20 0.39
GAA P10253 3/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
GABRA3 P34903 1/20 0.39
CYTH2 Q99418 1/20 0.38
ALDH1A1 P00352 2/20 0.37
MEN1 O00255 1/20 0.37
ALOX15 P16050 1/20 0.37
KMT2A Q03164 1/20 0.37
KEAP1 Q14145 1/20 0.36
CNR1 P21554 1/20 0.36
PKM P14618 1/20 0.35
CTRB1 P17538 1/20 0.35
CYP19A1 P11511 1/20 0.35
LMNA P02545 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2913347 0.82 RAB9A (0.42) GAAALDH1A1MEN1ALOX15KMT2A
SCHEMBL2910840 0.82 NPC1 (0.39) GAAALDH1A1MEN1KMT2ALMNA
SCHEMBL2911220 0.80 MAPT (0.39) ALDH1A1MEN1KMT2A
SCHEMBL2913076 0.80 CACNA1H (0.43) HSD17B10ALDH1A1MEN1KMT2ALMNA
SCHEMBL2913380 0.79 MAPT (0.36) ALDH1A1KMT2A
SCHEMBL2911192 0.78 ALDH1A1 (0.41) GAAALDH1A1MEN1KMT2APKM
SCHEMBL4092709 0.76 TP53 (0.31) GAAALDH1A1KMT2ALMNA
SCHEMBL4038640 0.76 NFE2L2 (0.31)
SCHEMBL2910781 0.74 RXRA (0.34) ALDH1A1MEN1KMT2A
SCHEMBL2909184 0.73 RAB9A (0.41) HSD17B10GAAALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080250572-A1 Stabilized body care products, household products, textiles and fabrics LUPIA JOSEPH A 2008-10-16 US claimed
US-20080221332-A1 Hindered Amine salt compounds WOOD MARVIN G 2008-09-11 US claimed
EP-1481679-B1 ANTIDEPRESSANT TAKEDA PHARMACEUTICAL (JP) 2010-08-25 EP disclosed
US-7750037-B2 Antidepressant TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-07-06 US disclosed
US-7632795-B2 Stabilized body care products, household products, textiles and fabrics CIBA SPECIALTY CHEMICALS CORPORATION (US) 2009-12-15 US disclosed
US-7615503-B2 Stabilized body care products, household products, textiles and fabrics CIBA SPECIALTY CHEMICALS CORP. (US) 2009-11-10 US disclosed
US-7612026-B2 Sterically hindered amine salts having an N-(alkoxy, cycloalkoxy or aralkoxy)2,2,6,6-tetraalkylsubstituted piperidine moiety; discoloration inhibition, colorfastness CIBA SPECIALTY CHEMICALS CORP. (US) 2009-11-03 US disclosed
US-7589035-B2 Stabilized body care products, household products, textiles and fabrics CIBA SPECIALTY CHEMICALS CORPORATION (US) 2009-09-15 US disclosed
US-20090205144-A1 Stabilized body care products, household products, textiles and fabrics LUPIA JOSEPH A 2009-08-20 US disclosed
US-20090092561-A1 Body-care and household products and compositions comprising specific sulfur-containing compounds BASF SE (DE) 2009-04-09 US disclosed
EP-1323716-B1 PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS TAKEDA PHARMACEUTICAL (JP) 2009-01-14 EP disclosed
US-20050187238-A1 Benzofuran derivatives, their production and use OHKAWA SHIGENORI (JP) 2005-08-25 US disclosed
US-20050148650-A1 Antidepressant TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-07-07 US disclosed
EP-1481679-A1 ANTIDEPRESSANT Takeda Chemical Industries, Ltd. (JP) 2004-12-01 EP disclosed
EP-1136477-B1 BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-03-10 EP disclosed
US-20040034049-A1 Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-02-19 US disclosed
EP-1323716-A1 PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS Takeda Chemical Industries, Ltd. (JP) 2003-07-02 EP disclosed
US-6479536-B1 Benzofuran derivatives, process for the preparation of the same and uses thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-11-12 US disclosed
US-20020160996-A1 Benzofuran derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2002-10-31 US disclosed
EP-1136477-A1 BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF Takeda Chemical Industries, Ltd. (JP) 2001-09-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050148650-A1 Antidepressant AKT1S1, AKT1, AKT2 FFAR4 459/4885HSD17B10 1001/4885GAA 4232/4885
US-20050187238-A1 Benzofuran derivatives, their production and use WDR1, WDR82, CBR1 FFAR4 2020/4885HSD17B10 378/4885GAA 2497/4885
US-20040034049-A1 Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells NES, HAT1, PROX1 FFAR4 3914/4885HSD17B10 895/4885GAA 3770/4885
US-20090092561-A1 Body-care and household products and compositions comprising specific sulfur-containing compounds DSC1, SCLY, DSG1 FFAR4 1733/4885HSD17B10 859/4885GAA 1217/4885
US-20020160996-A1 Benzofuran derivatives, their production and use PARK7, WDR1, WHR1 FFAR4 1701/4885HSD17B10 326/4885GAA 1706/4885
US-20080221332-A1 Hindered Amine salt compounds SLC7A1, H1-0, SLC3A2 FFAR4 3195/4885HSD17B10 1072/4885GAA 3412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.