Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15186297 | 0.89 | SIGMAR1 (0.48) | MAPTTP53MEN1KMT2AKDM4E | |
| SCHEMBL21803243 | 0.81 | GSK3B (0.44) | GSK3BTP53SMN1; SMN2NPC1RAB9A | |
| Bromide SCHEMBL28315346 | 0.79 | GSK3B (0.43) | GSK3BTP53SMN1; SMN2NPC1RAB9A | |
| Iodide SCHEMBL28993212 | 0.79 | GSK3B (0.43) | GSK3BTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29107248 | 0.77 | SIRT2 (0.40) | MAPTTP53SMN1; SMN2POLBMEN1 | |
| SCHEMBL29107250 | 0.77 | PPARG (0.41) | TP53BCHE | |
| SCHEMBL29107251 | 0.75 | PPARG (0.40) | GSK3BMAPTTP53THRBSMN1; SMN2 | |
| SCHEMBL29107246 | 0.75 | SMN1; SMN2 (0.48) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL27885890 | 0.75 | GSK3B (0.41) | GSK3BTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29107245 | 0.74 | MEN1 (0.51) | GSK3BMAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117069742-A | Spiro [ pyridine-thiazolidine ] compound and preparation method and application thereof | 五邑大学 | 2023-11-17 | — | — | CN | disclosed |