Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 9/20 | 0.53 |
| ▸ | CTSL | P07711 | 9/20 | 0.53 |
| ▸ | CTSK | P43235 | 6/20 | 0.53 |
| ▸ | CTSS | P25774 | 5/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913035 | 0.84 | CTSL (0.60) | CTSBCTSLCTSKCTSSCA1 | |
| SCHEMBL2917597 | 0.82 | CTSB (0.49) | CTSBCTSLCTSKCTSSCTSF | |
| SCHEMBL7511749 | 0.81 | CA2 (0.67) | CTSBCTSLCTSKCTSSCA1 | |
| SCHEMBL6185393 | 0.80 | CTSB (0.47) | CTSBCTSLCTSKCTSS | |
| SCHEMBL7507757 | 0.77 | CTSK (0.54) | CTSBCTSLCTSKCTSS | |
| SCHEMBL7488759 | 0.76 | CTSK (0.49) | CTSBCTSLCTSKCTSS | |
| SCHEMBL6182874 | 0.76 | CTSB (0.61) | CTSBCTSLCTSKCTSSCA1 | |
| SCHEMBL6183809 | 0.76 | CTSB (0.61) | CTSBCTSLCTSKCTSSCA1 | |
| SCHEMBL6182791 | 0.76 | CTSB (0.61) | CTSBCTSLCTSKCTSSCA1 | |
| SCHEMBL6183805 | 0.76 | CTSB (0.61) | CTSBCTSLCTSKCTSSCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028942-B1 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 2010-09-01 | — | — | EP | disclosed |
| US-20080027060-A1 | DIPEPTIDE NITRILES | ALTMANN EVA | 2008-01-31 | — | — | US | disclosed |
| US-20060235220-A1 | Dipeptide nitriles | MISSBACH MARTIN | 2006-10-19 | — | — | US | disclosed |
| US-20040110806-A1 | Dipeptide derivatives | ALTMANN EVA (CH) | 2004-06-10 | — | — | US | disclosed |
| US-20040029814-A1 | Dipeptide nitriles | ALTMANN EVA (CH) | 2004-02-12 | — | — | US | disclosed |
| US-6353017-B1 | INHIBITORS OF CATHESPINS USING DIPEPTIDE NITRILES AS ANTIINFLAMMATORY AGENTS AND ANTIARTHRITIC AGENTS | NOVARTIS AG (CH) | 2002-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110806-A1 | Dipeptide derivatives | CTSL, CTSZ, CTSS | CTSB 5/4885CTSL 1/4885CTSK 4/4885 |
| US-20040029814-A1 | Dipeptide nitriles | NOS1, CTSL, CTSS | CTSB 5/4885CTSL 2/4885CTSK 4/4885 |
| US-20060235220-A1 | Dipeptide nitriles | CTSL, CTSS, CTSB | CTSB 3/4885CTSL 1/4885CTSK 6/4885 |
| US-20080027060-A1 | DIPEPTIDE NITRILES | CTSL, CTSS, CTSB | CTSB 3/4885CTSL 1/4885CTSK 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.