Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | TEK | Q02763 | 4/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138058 | 0.87 | RAB9A (0.58) | KDRTEKRAB9ANPC1KDM4E | |
| SCHEMBL29138039 | 0.84 | KDR (0.52) | MPLKDRTEKROCK2RAB9A | |
| SCHEMBL29138090 | 0.82 | MPL (0.44) | MPLKDRTEKLCKBRAF | |
| SCHEMBL29138066 | 0.81 | NPC1 (0.51) | KDRTEKROCK2RAB9ANPC1 | |
| SCHEMBL29138054 | 0.81 | PDE4D (0.45) | MPLKDRTEKROCK2RAB9A | |
| SCHEMBL29138086 | 0.77 | KDR (0.62) | KDRTEKRAB9ANPC1KDM4E | |
| SCHEMBL29138040 | 0.72 | POLB (0.44) | KDRTEKKDM4EMAPTALDH1A1 | |
| SCHEMBL29138051 | 0.71 | AR (0.41) | KDRTEK | |
| SCHEMBL1264322 | 0.71 | TEK (0.71) | KDRTEKLCKBRAFMAPK14 | |
| SCHEMBL25184191 | 0.70 | MAPK9 (0.47) | GSK3BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117343081-A | MAT2A inhibitor, pharmaceutical composition and application thereof | 南京正大天晴制药有限公司 | 2024-01-05 | — | — | CN | disclosed |