Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 9/20 | 0.44 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | TEK | Q02763 | 7/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138054 | 0.89 | PDE4D (0.45) | MPLKDRTEKLCKBRAF | |
| SCHEMBL29138064 | 0.82 | MPL (0.45) | MPLKDRTEKLCKBRAF | |
| SCHEMBL29138058 | 0.81 | RAB9A (0.58) | KDRTEK | |
| SCHEMBL29138039 | 0.81 | KDR (0.52) | MPLKDRTEK | |
| SCHEMBL29138066 | 0.78 | NPC1 (0.51) | KDRTEKABL1LCKBRAF | |
| SCHEMBL29138086 | 0.78 | KDR (0.62) | KDRTEKLCKBRAFMAPK14 | |
| SCHEMBL13123119 | 0.74 | RAB9A (0.57) | — | |
| SCHEMBL29138040 | 0.73 | POLB (0.44) | KDRTEK | |
| SCHEMBL29138051 | 0.72 | AR (0.41) | KDRTEKAAK1 | |
| SCHEMBL8615570 | 0.70 | MPL (0.41) | MPLMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117343081-A | MAT2A inhibitor, pharmaceutical composition and application thereof | 南京正大天晴制药有限公司 | 2024-01-05 | — | — | CN | disclosed |