Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.62 |
| ▸ | TEK | Q02763 | 5/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138039 | 0.87 | KDR (0.52) | KDRTEKHTTNPC1RAB9A | |
| SCHEMBL29138066 | 0.87 | NPC1 (0.51) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29138058 | 0.83 | RAB9A (0.58) | KDRTEKHTTKDM4ENPC1 | |
| SCHEMBL29138054 | 0.81 | PDE4D (0.45) | KDRTEKRAB9ALCKBRAF | |
| SCHEMBL29138040 | 0.80 | POLB (0.44) | KDRTEKKDM4EPOLBALDH1A1 | |
| SCHEMBL29138090 | 0.78 | MPL (0.44) | KDRTEKLCKBRAFMAPK14 | |
| SCHEMBL1264518 | 0.77 | TEK (0.81) | KDRTEKLCKBRAFMAPK14 | |
| SCHEMBL1264888 | 0.77 | TEK (1.00) | KDRTEKLCKBRAFMAPK14 | |
| SCHEMBL29138064 | 0.77 | MPL (0.45) | KDRTEKKDM4ENPC1RAB9A | |
| SCHEMBL1265637 | 0.77 | KDR (0.62) | KDRTEKHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117343081-A | MAT2A inhibitor, pharmaceutical composition and application thereof | 南京正大天晴制药有限公司 | 2024-01-05 | — | — | CN | disclosed |