Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PROC | P04070 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221023 | 0.83 | ALOX5 (0.40) | CA2CA12CA1CA9CA4 | |
| SCHEMBL29941502 | 0.83 | ALOX5 (0.43) | CA2CA12CA1CA4CA7 | |
| SCHEMBL6222812 | 0.83 | ALOX5 (0.43) | CA2CA12CA1CA4CA7 | |
| SCHEMBL8128914 | 0.79 | POLB (0.41) | CA2CDK5CDK5R1ALOX5GRIN3B | |
| SCHEMBL10647330 | 0.72 | CA2 (0.54) | CA2CA12CA1CA9F10 | |
| SCHEMBL1107218 | 0.72 | ALOX5 (0.48) | ALOX5GRIN3BGRIN1GRIN2C | |
| SCHEMBL5262440 | 0.71 | AKR1B1 (0.67) | — | |
| SCHEMBL28017683 | 0.71 | ALOX5 (0.43) | ALOX5GRIN3BGRIN1GRIN2CNAMPT | |
| SCHEMBL10650164 | 0.71 | CA2 (0.49) | CA2CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL10647443 | 0.71 | CA2 (0.53) | CA2CA12CA1CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271273-A2 | Thieno-and furopyridine sulfonamides | MERCK & CO. INC. (US) | 1988-06-15 | — | — | EP | claimed |
| EP-1963337-B1 | THIENO[2,3-b]PYRIDINE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2010-09-01 | — | — | EP | disclosed |
| US-20100022521-A1 | COMPOUNDS | HANSA METALLWERKE AG (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20090118323-A1 | ANTITUMOR BENZOYLSULFONAMIDES | MADER MARY MARGARET | 2009-05-07 | — | — | US | disclosed |
| EP-1963337-A1 | NEW COMPOUNDS | Richter Gedeon NYRT (HU) | 2008-09-03 | — | — | EP | disclosed |
| EP-1565438-B1 | ANTITUMOR BENZOYLSULFONAMIDES | LILLY CO ELI (US) | 2007-10-17 | — | — | EP | disclosed |
| US-7282595-B2 | Antitumor benzoylsulfonamides | ELI LILLY AND COMPANY (US) | 2007-10-16 | — | — | US | disclosed |
| WO-2007072095-A1 | NEW COMPOUNDS | RICHTER GEDEON NYRT. (HU) | 2007-06-28 | — | — | WO | disclosed |
| US-20060106053-A1 | Antitumor benzoylsulfonamides | ELI LILLY AND COMPANY | 2006-05-18 | — | — | US | disclosed |
| EP-1565438-A1 | ANTITUMOR BENZOYLSULFONAMIDES | ELI LILLY AND COMPANY (US) | 2005-08-24 | — | — | EP | disclosed |
| US-6013655-A | HYPOTENSIVE AGENTS; RESPIRATORY SYSTEM DIISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| US-6013655-A | HYPOTENSIVE AGENTS; RESPIRATORY SYSTEM DIISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0898571-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5804585-A | INHIBIT BINDING OF ENDOTHELIN PEPTIDE TO ENDOTHELIN RECEPTORS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-09-08 | — | — | US | disclosed |
| US-5804585-A | INHIBIT BINDING OF ENDOTHELIN PEPTIDE TO ENDOTHELIN RECEPTORS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-09-08 | — | — | US | disclosed |
| WO-1997039000-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1997-10-23 | — | — | WO | disclosed |
| EP-0271273-A2 | Thieno-and furopyridine sulfonamides | MERCK & CO. INC. (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4731368-A | Thienopyridine sulfonamides and their ophthalmological formulation | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4731368-A | Thienopyridine sulfonamides and their ophthalmological formulation | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4731368-A | Thienopyridine sulfonamides and their ophthalmological formulation | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118323-A1 | ANTITUMOR BENZOYLSULFONAMIDES | HCCS, GLS2, GLS | CA2 1594/4885CA12 122/4885CA1 428/4885 |
| US-20060106053-A1 | Antitumor benzoylsulfonamides | HCCS, GLS2, GLS | CA2 1594/4885CA12 122/4885CA1 428/4885 |
| US-20100022521-A1 | COMPOUNDS | GRM5, GRM3, GRM1 | CA2 885/4885CA12 3277/4885CA1 1046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.