Lexacalcitol

Lexacalcitol

SCHEMBL2917

C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@@H](C)OCCCC(O)(CC)CC)CC[C@@H]23)C[C@@H](O)C[C@@H]1O

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ VDR P11473 11/20 0.83
▸ MAPT P10636 2/20 0.67
▸ ADORA3 P0DMS8 2/20 0.67
▸ SLC6A2 P23975 2/20 0.67
▸ AGTR1 P30556 2/20 0.67
▸ NR1I2 O75469 1/20 0.67
▸ ABCB11 O95342 1/20 0.67
▸ GC P02774 1/20 0.67
▸ PGR P06401 1/20 0.67
▸ RXRA P19793 1/20 0.67
▸ CHRM3 P20309 1/20 0.67
▸ CNR1 P21554 1/20 0.67
▸ HTR2C P28335 1/20 0.67
▸ MAPK1 P28482 1/20 0.67
▸ SLC6A4 P31645 1/20 0.67
▸ ADRA1A P35348 1/20 0.67
▸ PTGS2 P35354 1/20 0.67
▸ OPRD1 P41143 1/20 0.67
▸ OPRK1 P41145 1/20 0.67
▸ SLC6A3 Q01959 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lexacalcitol SCHEMBL5617343 1.00 VDR (0.83) VDRMAPTADORA3SLC6A2AGTR1
Lexacalcitol SCHEMBL5617341 1.00 VDR (0.83) VDRMAPTADORA3SLC6A2AGTR1
Lexacalcitol SCHEMBL24066829 1.00 VDR (0.83) VDRMAPTADORA3SLC6A2AGTR1
SCHEMBL30956326 0.95 VDR (0.85) VDRMAPTADORA3SLC6A2AGTR1
SCHEMBL9754276 0.92 VDR (0.91) VDRMAPTADORA3SLC6A2AGTR1
SCHEMBL9754278 0.92 VDR (0.91) VDRMAPTADORA3SLC6A2AGTR1
SCHEMBL14027728 0.92 VDR (0.80) VDRMAPTADORA3SLC6A2AGTR1
SCHEMBL6256864 0.91 VDR (0.72) VDRMAPTADORA3SLC6A2AGTR1
SCHEMBL12516472 0.90 VDR (0.77) VDRMAPTADORA3ABCB11PGR
SCHEMBL20115744 0.90 VDR (0.77) VDRMAPTADORA3ABCB11PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 — — US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 — — US claimed
US-20260028400-A1 ANTI-ROR1 ANTIBODY AND USE THEREOF AIMED BIO INC (KR) 2026-01-29 — — US claimed
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) 2025-11-06 — — US claimed
EP-4642492-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE FUNCTIONAL SMALL MOLECULE COMPOUNDS FOR ENHANCED TREATMENT OF REFRACTORY DISEASES Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 — — EP claimed
EP-4642484-A1 TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 — — EP claimed
US-20250270320-A1 ANTI-PD-1 ANTIBODY AND USES THEREOF EUTILEX CO., LTD. (KR) 2025-08-28 — — US claimed
WO-2025122699-A1 CDC7 INHIBITOR COMBINATIONAL THERAPY Lin Bioscience, Inc. (TW) 2025-06-12 — — WO claimed
EP-4563597-A1 ANTI-ROR1 ANTIBODY AND USE THEREOF AIMED BIO INC. (KR) 2025-06-04 — — EP claimed
WO-2025111447-A1 TREATMENT OF CANCER WITH DRUG COMBINATIONS FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (US) 2025-05-30 — — WO claimed
WO-2007036802-A2 SUBLINGUAL DOSAGE FORM COMRISING VITAMIN D ANALOGUE, IN PARTICULAR CALCITRIOL TEVA PHARMACEUTICAL INDUSTRIES LIMITED (GB) 2007-04-05 — — WO claimed
EP-1748784-A2 INDUCTION OF INNATE IMMUNITY BY VITAMIN D3 AND ITS ANALOGS Cedars-Sinai Medical Center (US) 2007-02-07 — — EP claimed
WO-2005115403-A2 INDUCTION OF INNATE IMMUNITY BY VITAMIN D3 AND ITS ANALOGS CEDARS-SINAI MEDICAL CENTER (US) 2005-12-08 — — WO claimed
US-20040082557-A1 Methods for treating estrogen-dependent disorders PHARMACIA ITALIA S.P.A. (IT) 2004-04-29 — — US claimed
US-20040024044-A1 Exemestane as chemopreventing agent PHARMACIA ITALIA S.P.A. (IT) 2004-02-05 — — US claimed
EP-1377298-A2 COMBINED METHOD FOR TREATING HORMONO-DEPENDENT DISORDERS Pharmacia Italia S.p.A. (IT) 2004-01-07 — — EP claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 — — EP claimed
EP-1317270-A1 EXEMESTANE FOR THE TREATMENT OF OESTROGEN-DEPENDENT CANCERS Pharmacia Italia S.p.A. (IT) 2003-06-11 — — EP claimed
WO-2002072106-A2 COMBINED METHOD FOR TREATING HORMONO-DEPENDENT DISORDERS WITH EXEMESTANE PHARMACIA ITALIA SPA (IT) 2002-09-19 — — WO claimed
WO-2002020020-A1 EXEMESTANE AS CHEMOPREVENTING AGENT PHARMACIA ITALIA S.P.A. (IT) 2002-03-14 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES FCGR2A, FCGR3B, FCGR1A VDR 3577/4885MAPT 778/4885ADORA3 2375/4885
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule CD4, TAP1, MCTS1 VDR 2627/4885MAPT 1889/4885ADORA3 4679/4885
US-20260028400-A1 ANTI-ROR1 ANTIBODY AND USE THEREOF RORB, RORC, RORA VDR 571/4885MAPT 1814/4885ADORA3 1894/4885
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS DCLRE1A, CCR3, CCR8 VDR 1706/4885MAPT 4363/4885ADORA3 1819/4885
US-20040082557-A1 Methods for treating estrogen-dependent disorders CYP19A1, BRCA1, ESR2 VDR 916/4885MAPT 4675/4885ADORA3 2282/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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