Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 6/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | USP5 | P45974 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.30 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.30 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.30 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.30 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19457471 | 0.79 | LMNA (0.43) | KDM4EALDH1A1HPGDPOLBKMT2A | |
| SCHEMBL29181724 | 0.77 | GPR139 (0.32) | GPR139KMT2A | |
| SCHEMBL29098708 | 0.73 | SLC6A9 (0.39) | GPR139SLC6A9ALDH1A1HPGDSLC6A5 | |
| SCHEMBL24993293 | 0.70 | KDM4E (0.45) | KDM4EALDH1A1HPGDPOLBKMT2A | |
| SCHEMBL29012853 | 0.67 | GPR139 (0.42) | GPR139SLC6A9PPARGNR2E3NCOR2 | |
| SCHEMBL28863527 | 0.67 | SLC6A9 (0.35) | GPR139SLC6A9ALDH1A1HPGDSLC6A5 | |
| SCHEMBL16334956 | 0.65 | DAO (0.50) | KDM4EALDH1A1ALOX15KMT2A | |
| SCHEMBL13994843 | 0.64 | ALOX15 (0.44) | KDM4EALDH1A1HPGDALOX15KMT2A | |
| SCHEMBL29201822 | 0.63 | DAO (0.41) | KDM4EALDH1A1HPGDALOX15POLB | |
| SCHEMBL28863530 | 0.62 | EGLN1 (0.35) | GPR139ALDH1A1KMT2ATDP1PSMB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447443-A | Method for preparing rotirana intermediate by one-pot method | 北京康立生医药技术开发有限公司 | 2024-01-26 | — | — | CN | claimed |
| CN-117447443-A | Method for preparing rotirana intermediate by one-pot method | 北京康立生医药技术开发有限公司 | 2024-01-26 | — | — | CN | disclosed |