Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.67 |
| ▸ | GRM5 | P41594 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17224548 | 0.97 | APP (0.63) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL9610050 | 0.91 | APP (0.55) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL12873263 | 0.90 | APP (0.52) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL1820120 | 0.88 | HDAC8 (0.58) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL9928719 | 0.85 | NOTUM (0.61) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL13900784 | 0.85 | NOTUM (0.61) | APPGRM5MAPTNOTUMNPC1 | |
| SCHEMBL1649302 | 0.85 | HDAC8 (0.55) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL12873256 | 0.85 | ASIC3 (0.56) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL4410475 | 0.84 | GRM5 (0.52) | APPGRM5MAPTPIK3CDPIK3CA | |
| SCHEMBL4324850 | 0.83 | ASIC3 (0.53) | APPGRM5PIK3CDPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141248-A | Protein crystallization nucleating agent and preparation method thereof | 深圳先进技术研究院 | 2022-10-04 | — | — | CN | claimed |
| EP-3469370-B1 | BACKGROUND BLOCKERS FOR BINDING ASSAYS | RADIOMETER TURKU OY (FI) | 2024-05-01 | — | — | EP | disclosed |
| CN-114702437-B | Sonogashira coupling method for heteroaryl phosphonium salt and terminal alkyne | 南京工业大学 | 2023-05-30 | — | — | CN | disclosed |
| US-11614445-B2 | Background blockers for binding assays | RADIOMETER TURKU OY (FI) | 2023-03-28 | — | — | US | disclosed |
| CN-115141248-A | Protein crystallization nucleating agent and preparation method thereof | 深圳先进技术研究院 | 2022-10-04 | — | — | CN | disclosed |
| CN-109313198-B | Background blockers for binding assays | 雷度米特图尔库公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114702437-A | Sonogashira coupling method of heteroaryl phosphonium salt and terminal alkyne | 南京工业大学 | 2022-07-05 | — | — | CN | disclosed |
| EP-3990446-A1 | NOVEL LUMINESCENT LANTHANIDE CHELATE REPORTERS, BIOSPECIFIC BINDING REACTANTS LABELLED WITH NOVEL LUMINESCENT LANTHANIDE CHELATE REPORTERS AND THEIR USE | Radiometer Turku Oy (FI) | 2022-05-04 | — | — | EP | disclosed |
| CN-114026070-A | Novel luminescent lanthanide chelate reporter molecules, biospecific binding reactants labeled with novel luminescent lanthanide chelate reporter molecules and uses thereof | 雷度米特图尔库公司 | 2022-02-08 | — | — | CN | disclosed |
| US-20210395606-A1 | CHROMOPHORIC STRUCTURES FOR MACROCYCLIC LANTHANIDE CHELATES | RADIOMETER TURKU OY (FI) | 2021-12-23 | — | — | US | disclosed |
| EP-1896448-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION | Wyeth (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2008020113-A1 | LUMINESCENT LANTHANIDE LABELLING REAGENTS AND THEIR USE | ABACUS DIAGNOSTICA OY (FI) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007005404-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | disclosed |
| WO-2007005404-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | disclosed |
| US-20070004730-A1 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
| US-20070004730-A1 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
| US-7105707-B2 | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds | PHARMACORE, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20050137402-A1 | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds | DSM N.V. (NL) | 2005-06-23 | — | — | US | disclosed |
| US-5576336-A | Indole derivatives as dopamine D4 antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| WO-1994021627-A1 | INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004730-A1 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation | BACE1, BACE2, APP | APP 3/4885GRM5 196/4885MAPT 15/4885 |
| US-20050137402-A1 | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds | NAT1, B3GNT2, NISCH | APP 1495/4885GRM5 3019/4885MAPT 2963/4885 |
| US-20210395606-A1 | CHROMOPHORIC STRUCTURES FOR MACROCYCLIC LANTHANIDE CHELATES | UACA, LGALS3BP, CACYBP | APP 4874/4885GRM5 2535/4885MAPT 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.