SCHEMBL1820120

SCHEMBL1820120

C(#Cc1ccncc1)c1ccncc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.58
GRM5 P41594 3/20 0.52
FFAR1 O14842 1/20 0.48
LMNA P02545 2/20 0.47
MAPT P10636 2/20 0.47
PIK3CA P42336 2/20 0.47
MTOR P42345 2/20 0.47
PIK3CD O00329 1/20 0.47
PIK3CG P48736 1/20 0.47
PDK1 Q15118 1/20 0.47
APP P05067 2/20 0.44
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP2D6 P10635 1/20 0.42
CHRM1 P11229 1/20 0.42
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
KCNA1 Q09470 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1649302 0.97 HDAC8 (0.55) HDAC8GRM5FFAR1LMNAMAPT
SCHEMBL13907329 0.91 HDAC8 (0.50) HDAC8GRM5FFAR1LMNAMAPT
Methyl Alcohol SCHEMBL28280712 0.91 GRM5 (0.52) HDAC8GRM5FFAR1LMNAMAPT
SCHEMBL13907339 0.91 HDAC8 (0.50) HDAC8GRM5FFAR1LMNAMAPT
SCHEMBL2925968 0.88 APP (0.67) HDAC8GRM5FFAR1MAPTPIK3CA
SCHEMBL9610040 0.88 MAPT (0.53) HDAC8GRM5FFAR1LMNAMAPT
SCHEMBL1190707 0.87 HDAC8 (0.52) HDAC8GRM5FFAR1LMNAMAPT
SCHEMBL11957582 0.86 GRM5 (0.48) HDAC8GRM5FFAR1LMNAMAPT
SCHEMBL13219274 0.86 MAPT (0.58) HDAC8GRM5FFAR1LMNAMAPT
SCHEMBL17224548 0.86 APP (0.63) HDAC8GRM5FFAR1MAPTPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636634-B2 Fluorinated MOF materials having rectangular channels, method of synthesizing MOF materials and methods of using MOF materials including for CO2 capture KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2026-05-26 US claimed
US-12576387-B2 Porous metal-organic framework, method for producing the same, adsorbent, and method for separating carbon dioxide KABUSHIKI KAISHA TOSHIBA (JP) 2026-03-17 US claimed
EP-4578530-A1 PROCESS FOR THE SEPARATION OF KRYPTON FROM A WASTE GAS STREAM Immaterial Ltd (GB) 2025-07-02 EP claimed
US-20240316530-A1 FLUORINATED MOF MATERIALS HAVING RECTANGULAR CHANNELS, METHOD OF SYNTHESIZING MOF MATERIALS AND METHODS OF USING MOF MATERIALS INCLUDING FOR CO2 CAPTURE KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2024-09-26 US claimed
WO-2024196666-A1 FLUORINATED MOF MATERIALS HAVING RECTANGULAR CHANNELS, METHOD OF SYNTHESIZING MOF MATERIALS AND METHODS OF USING MOF MATERIALS INCLUDING FOR CO2 CAPTURE KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2024-09-26 WO claimed
WO-2024151728-A1 METHODS FOR MANUFACTURE OF FLUORINATED PILLAR METAL-ORGANIC FRAMEWORK MATERIALS KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2024-07-18 WO claimed
US-20240239826-A1 METHODS FOR MANUFACTURE OF FLUORINATED PILLAR METAL-ORGANIC FRAMEWORK MATERIALS SAUDI ARABIAN OIL COMPANY (SA) 2024-07-18 US claimed
US-11819795-B2 Trace and low concentration CO2 removal methods and apparatus utilizing metal organic frameworks KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2023-11-21 US claimed
CN-116903867-A Porous metal-organic structure, method for producing same, adsorbent, and method for separating carbon dioxide 株式会社东芝 2023-10-20 CN claimed
US-20230330626-A1 POROUS METAL-ORGANIC FRAMEWORK, METHOD FOR PRODUCING THE SAME, ADSORBENT, AND METHOD FOR SEPARATING CARBON DIOXIDE KABUSHIKI KAISHA TOSHIBA (JP) 2023-10-19 US claimed
US-8741030-B2 Metal complex, and adsorbent, occlusion material and separator material made from same KURARAY CO., LTD. (JP) 2014-06-03 US claimed
US-8592626-B2 Metal complex and manufacturing method therefor KURARAY CO., LTD. (JP) 2013-11-26 US claimed
EP-2325160-B1 METAL COMPLEX AND MANUFACTURING METHOD THEREFOR KURARAY CO (JP) 2013-10-16 EP claimed
EP-2540708-A1 METAL COMPLEX, AND ADSORBENT, OCCLUSION MATERIAL AND SEPARATOR MATERIAL MADE FROM SAME Kuraray Co., Ltd. (JP) 2013-01-02 EP claimed
US-20120312164-A1 METAL COMPLEX, AND ADSORBENT, OCCLUSION MATERIAL AND SEPARATOR MATERIAL MADE FROM SAME KURARAY CO., LTD. (JP) 2012-12-13 US claimed
EP-2507252-A1 HEAT-SENSITIVE SPIN-TRANSITION MATERIALS DOPED WITH ONE OR MORE FLUORESCENT AGENTS Centre National De La Recherche Scientifique CNRS (FR) 2012-10-10 EP claimed
US-20110237796-A1 METAL COMPLEX AND MANUFACTURING METHOD THEREFOR KURARAY CO., LTD. (JP) 2011-09-29 US claimed
EP-2325160-A1 METAL COMPLEX AND MANUFACTURING METHOD THEREFOR Kuraray Co., Ltd. (JP) 2011-05-25 EP claimed
WO-2011058277-A1 HEAT-SENSITIVE SPIN-TRANSITION MATERIALS DOPED WITH ONE OR MORE FLUORESCENT AGENTS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) 2011-05-19 WO claimed
US-5104948-A Electroconductive, oxidation resistance UNIVERSITY OF LOWELL (US) 1992-04-14 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237796-A1 METAL COMPLEX AND MANUFACTURING METHOD THEREFOR SLC39A11, SLC39A7, SLC39A14 HDAC8 2274/4885GRM5 1586/4885FFAR1 607/4885
US-12636634-B2 Fluorinated MOF materials having rectangular channels, method of synthesizing MOF materials and methods of using MOF materials including for CO2 capture MLX, BMP4, F13B HDAC8 2881/4885GRM5 1915/4885FFAR1 1584/4885
US-12576387-B2 Porous metal-organic framework, method for producing the same, adsorbent, and method for separating carbon dioxide OXGR1, TET1, MT-CO2 HDAC8 3939/4885GRM5 2332/4885FFAR1 3118/4885
US-20240239826-A1 METHODS FOR MANUFACTURE OF FLUORINATED PILLAR METAL-ORGANIC FRAMEWORK MATERIALS POF1B, TPR, FGFR1 HDAC8 639/4885GRM5 1404/4885FFAR1 576/4885
US-20120312164-A1 METAL COMPLEX, AND ADSORBENT, OCCLUSION MATERIAL AND SEPARATOR MATERIAL MADE FROM SAME OGDH, CAD, F2 HDAC8 715/4885GRM5 166/4885FFAR1 986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.