Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069525 | 0.88 | HSP90AB1 (0.56) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL2927454 | 0.88 | HSP90AB1 (0.56) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL13176152 | 0.88 | HSP90AB1 (0.64) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL21891794 | 0.83 | HSP90AB1 (0.75) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL25281597 | 0.82 | HSP90AB1 (0.58) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL12368043 | 0.82 | CYP4Z1 (0.46) | HSP90AB1ALDH1A1GAASMN1; SMN2HMGB1 | |
| SCHEMBL8204330 | 0.82 | HSP90AB1 (0.68) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL24133044 | 0.81 | HSP90AB1 (0.56) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL24132737 | 0.81 | HSP90AB1 (0.56) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL5992538 | 0.81 | PTGS1 (0.44) | HSP90AB1ALDH1A1GAACYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46024-E1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-RE46024-E1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-RE46024-E1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-20130165355-A1 | Hydroxychroman Derivatives As Engine Oil Antioxidants | THE LUBRIZOL CORPORATION (US) | 2013-06-27 | — | — | US | disclosed |
| US-8461235-B2 | Use of polymer powder containing UV absorber for the stabilisation of polymers against the effects of UV radiation | BASF SE (DE) | 2013-06-11 | — | — | US | disclosed |
| US-8048831-B2 | Dispersant reaction product with antioxidant capability | AFTON CHEMICAL CORPORATION (US) | 2011-11-01 | — | — | US | disclosed |
| US-7807674-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807674-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807674-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2010-10-05 | — | — | US | disclosed |
| EP-2230906-A1 | NANOPARTICULATE ANIDULAFUNGIN COMPOSITIONS AND METHODS FOR MAKING THE SAME | Elan Pharma International Limited (IE) | 2010-09-29 | — | — | EP | disclosed |
| US-20080318813-A1 | Dispersant reaction product with antioxidant capability | AFTON CHEMICAL CORPORATION | 2008-12-25 | — | — | US | disclosed |
| US-7452882-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7452882-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7452882-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2008-11-18 | — | — | US | disclosed |
| EP-1919878-A1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | F. Hoffmann-Roche AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| US-20070032494-A1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. | 2007-02-08 | — | — | US | disclosed |
| US-20070032494-A1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. | 2007-02-08 | — | — | US | disclosed |
| US-20070032494-A1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. | 2007-02-08 | — | — | US | disclosed |
| WO-2007009913-A1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009913-A1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032494-A1 | Thyroid hormone analogs | THRA, THRB, TPO | HSP90AB1 854/4885ALDH1A1 991/4885GAA 2148/4885 |
| US-20080318813-A1 | Dispersant reaction product with antioxidant capability | PRUNE1, LPO, COMT | HSP90AB1 4101/4885ALDH1A1 1297/4885GAA 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.