Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 10/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27684323 | 0.74 | ALDH1A1 (0.35) | MEN1KMT2A | |
| SCHEMBL31326790 | 0.73 | TSHR (0.35) | — | |
| SCHEMBL30023154 | 0.71 | ELANE (0.37) | SOAT1MEN1KMT2A | |
| SCHEMBL27938466 | 0.70 | ESR1 (0.34) | — | |
| SCHEMBL27414312 | 0.70 | LIPG (0.37) | PTPN1 | |
| SCHEMBL30137202 | 0.70 | LIPG (0.37) | PTPN1 | |
| SCHEMBL29157733 | 0.69 | LTA4H (0.39) | PTPN1MEN1KMT2A | |
| SCHEMBL2033434 | 0.69 | CA2 (0.34) | — | |
| SCHEMBL2445501 | 0.66 | PSIP1 (0.61) | — | |
| Benzene SCHEMBL6390523 | 0.66 | PSIP1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797051-B1 | BENZOXAZINE AND QUINOXALINE DERIVATIVES AND USES | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |
| CN-100532369-C | Benzoxazine derivatives and uses thereof | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | CN | disclosed |
| US-7378415-B2 | Benzoxazine and quinoxaline derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2008-05-27 | — | — | US | disclosed |
| CN-101031554-A | Benzoxazine and quinoxaline derivatives and uses | HOFFMANN LA ROCHE (CH) | 2007-09-05 | — | — | CN | disclosed |
| EP-1694656-B1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2007-08-29 | — | — | EP | disclosed |
| EP-1797051-A1 | BENZOXAZINE AND QUINOXALINE DERIVATIVES AND USES | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| US-7202241-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2007-04-10 | — | — | US | disclosed |
| CN-1890227-A | Benzoxazine derivatives and uses thereof | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |
| EP-1694656-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-30 | — | — | EP | disclosed |
| US-20060106012-A1 | Benzoxazine and quinoxaline derivatives and uses thereof | ROCHE PALO ALTO LLC | 2006-05-18 | — | — | US | disclosed |
| WO-2006037481-A1 | BENZOXAZINE AND QUINOXALINE DERIVATIVES AND USES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-13 | — | — | WO | disclosed |
| WO-2005058847-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |
| US-20050124613-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124613-A1 | Benzoxazine derivatives and uses thereof | XDH, CYP4X1, CYP2C9 | SOAT1 4514/4885EPHX2 902/4885GSR 1142/4885 |
| US-20060106012-A1 | Benzoxazine and quinoxaline derivatives and uses thereof | XDH, PDHX, HAX1 | SOAT1 4311/4885EPHX2 1746/4885GSR 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.