Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 13/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29315913 | 0.78 | ROCK1 (0.39) | ROCK2ROCK1 | |
| SCHEMBL29315909 | 0.77 | ROCK2 (0.46) | ROCK2ROCK1 | |
| SCHEMBL31009157 | 0.72 | POLQ (0.46) | POLQROCK2ROCK1 | |
| SCHEMBL29314127 | 0.70 | POLQ (0.41) | POLQNPSR1GAASMN1; SMN2KDM4E | |
| SCHEMBL29314126 | 0.70 | ROCK2 (0.34) | ROCK2ROCK1 | |
| SCHEMBL31009207 | 0.67 | POLQ (0.50) | POLQROCK2 | |
| SCHEMBL29316278 | 0.66 | NPBWR1 (0.39) | ROCK2ROCK1 | |
| SCHEMBL29314124 | 0.64 | SMN1; SMN2 (0.40) | POLQNPSR1GAASMN1; SMN2KDM4E | |
| SCHEMBL30716959 | 0.61 | POLQ (0.70) | POLQ | |
| SCHEMBL29135502 | 0.61 | POLQ (0.70) | POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |