Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 8/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29314125 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2POLQNPSR1GAAMEN1 | |
| SCHEMBL29314123 | 0.70 | ALDH1A1 (0.34) | POLQNPSR1GAAMEN1KMT2A | |
| SCHEMBL29314114 | 0.68 | POLQ (0.32) | POLQGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL29314117 | 0.67 | POLQ (0.31) | POLQ | |
| SCHEMBL29314121 | 0.64 | POLQ (0.44) | SMN1; SMN2POLQNPSR1GAAALDH1A1 | |
| SCHEMBL29314127 | 0.62 | POLQ (0.41) | SMN1; SMN2POLQNPSR1GAAMEN1 | |
| SCHEMBL29313852 | 0.62 | POLQ (0.41) | POLQKMT2AALDH1A1 | |
| SCHEMBL29313860 | 0.61 | POLQ (0.34) | POLQ | |
| SCHEMBL21785057 | 0.60 | OPRM1 (0.49) | SMN1; SMN2GAAALDH1A1KDM4EPOLB | |
| SCHEMBL8443789 | 0.59 | SMN1; SMN2 (0.47) | SMN1; SMN2NPSR1GAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |