Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.49 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 3/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29313569 | 0.78 | TNK2 (0.48) | CHEK1MAP3K8MAPK1 | |
| SCHEMBL29313579 | 0.76 | KAT2B (0.42) | MAP3K8PRKCQLRRK2 | |
| SCHEMBL29313573 | 0.74 | LRRK2 (0.47) | CHEK1PRKCQLRRK2 | |
| SCHEMBL23019347 | 0.71 | PRKCQ (0.41) | PRKCQSYKLRRK2 | |
| SCHEMBL29313773 | 0.71 | CCNA2 (0.46) | MERTKPRKCQSYKLRRK2 | |
| SCHEMBL1598417 | 0.70 | CHEK1 (0.46) | CHEK1MAP3K8 | |
| SCHEMBL1598420 | 0.70 | CHEK1 (0.46) | CHEK1MAP3K8 | |
| SCHEMBL29313719 | 0.69 | AURKA (0.38) | SYKLRRK2 | |
| SCHEMBL29313606 | 0.69 | PTK2 (0.40) | PRKCQSYKLRRK2 | |
| SCHEMBL1598410 | 0.68 | MAP3K8 (0.42) | CHEK1MAP3K8SYKKCNH2EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782986-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-10 | — | — | EP | disclosed |