Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930744 | 0.90 | HCRTR2 (0.37) | HCRTR2CYP46A1HCRTR1 | |
| SCHEMBL2924244 | 0.87 | CYP46A1 (0.39) | HCRTR2CYP46A1HCRTR1 | |
| SCHEMBL2932492 | 0.86 | MKNK1 (0.40) | HCRTR2MAPTKDM4EALDH1A1CYP46A1 | |
| SCHEMBL2923800 | 0.85 | HCRTR1 (0.48) | HCRTR2HCRTR1HTT | |
| SCHEMBL2930955 | 0.84 | HCRTR2 (0.38) | HCRTR2CYP46A1HCRTR1POLB | |
| SCHEMBL2931914 | 0.83 | HCRTR2 (0.39) | HCRTR2CYP46A1HCRTR1POLB | |
| SCHEMBL2931040 | 0.83 | HCRTR2 (0.40) | HCRTR2HCRTR1POLB | |
| SCHEMBL2930074 | 0.83 | SLC6A7 (0.35) | HCRTR2HCRTR1 | |
| SCHEMBL2933639 | 0.81 | PAX8 (0.39) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL2923507 | 0.80 | PAX8 (0.39) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |