Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930742 | 0.89 | PIK3CA (0.35) | PIK3CAALDH1A1CYP46A1HCRTR2HCRTR1 | |
| SCHEMBL2924242 | 0.87 | FABP4 (0.42) | KDM4EPIK3CAALDH1A1CYP46A1HCRTR2 | |
| SCHEMBL2923799 | 0.86 | HCRTR1 (0.47) | HTTPIK3CAHCRTR2HCRTR1 | |
| SCHEMBL2932494 | 0.86 | HCRTR2 (0.38) | MKNK1MKNK2KDM4EHTTLMNA | |
| SCHEMBL2930954 | 0.84 | POLB (0.39) | PIK3CAALDH1A1CYP46A1HCRTR2HCRTR1 | |
| SCHEMBL2930073 | 0.82 | PDE4B (0.37) | HCRTR2HCRTR1 | |
| SCHEMBL2931039 | 0.82 | HCRTR2 (0.39) | HCRTR2HCRTR1PIK3CD | |
| SCHEMBL2931912 | 0.82 | APOB (0.38) | MAPTALDH1A1HCRTR2HCRTR1PIK3CD | |
| SCHEMBL2933638 | 0.80 | NPC1 (0.39) | KDM4EMAPTALDH1A1HCRTR2HCRTR1 | |
| SCHEMBL2923504 | 0.80 | PAX8 (0.38) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |