Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991076 | 0.86 | POLB (0.30) | POLB | |
| SCHEMBL29758999 | 0.84 | ALDH1A1 (0.32) | POLBEPHX1 | |
| SCHEMBL2992534 | 0.84 | POLB (0.31) | POLB | |
| SCHEMBL30799838 | 0.83 | POLB (0.33) | POLBEPHX2MEN1GAAKMT2A | |
| SCHEMBL2999754 | 0.82 | — | — | |
| SCHEMBL29625476 | 0.80 | — | — | |
| SCHEMBL29758995 | 0.76 | ALDH1A1 (0.30) | — | |
| SCHEMBL384421 | 0.76 | ALDH1A1 (0.37) | POLBMEN1KMT2AEPHX1 | |
| SCHEMBL2009267 | 0.74 | — | — | |
| SCHEMBL3000801 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12559464-B2 | Quinazolinone dione compounds and uses thereof | EDGEWISE THERAPEUTICS, INC. (US) | 2026-02-24 | — | — | US | disclosed |
| EP-4688756-A1 | QUINAZOLINE DIONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2026-02-11 | — | — | EP | disclosed |
| EP-4688748-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-12448369-B2 | Quinolinone amide compounds and uses thereof | EDGEWISE THERAPEUTICS, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250026740-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. | 2025-01-23 | — | — | US | disclosed |
| US-20250026726-A1 | QUINAZOLINONE DIONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. | 2025-01-23 | — | — | US | disclosed |
| US-12122730-B2 | Methods of carbon-carbon bond fragmentation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-10-22 | — | — | US | disclosed |
| WO-2024206339-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024206345-A1 | QUINAZOLINE DIONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-10-03 | — | — | WO | disclosed |
| US-11351147-B2 | Short syntheses of (−)-picrotoxinin and related compounds | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-06-07 | — | — | US | disclosed |
| US-20220169580-A1 | METHODS OF CARBON-CARBON BOND FRAGMENTATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-06-02 | — | — | US | disclosed |
| US-20220040147-A1 | SHORT SYNTHESES OF (-)-PICROTOXININ AND RELATED COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE | 2022-02-10 | — | — | US | disclosed |
| WO-2022031313-A1 | SHORT SYNTHESES OF (-)-PICROTOXININ AND RELATED COMPOUNDS | CROSSLEY STEVEN W M (US) | 2022-02-10 | — | — | WO | disclosed |
| EP-3944739-A2 | METHODS OF CARBON-CARBON BOND FRAGMENTATION | The Regents of the University of California (US) | 2022-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11351147-B2 | Short syntheses of (−)-picrotoxinin and related compounds | GABRA5, GABRE, GABRP | POLB 3682/4885EPHX2 1564/4885MEN1 1847/4885 |
| US-20220169580-A1 | METHODS OF CARBON-CARBON BOND FRAGMENTATION | CYCS, COX6C, COXFA4L2 | POLB 336/4885EPHX2 2377/4885MEN1 4097/4885 |
| US-12448369-B2 | Quinolinone amide compounds and uses thereof | TNNI3, TNNT2, COQ8A | POLB 2974/4885EPHX2 3250/4885MEN1 3354/4885 |
| US-20220040147-A1 | SHORT SYNTHESES OF (-)-PICROTOXININ AND RELATED COMPOUNDS | GABRA5, GABRE, GABRP | POLB 3702/4885EPHX2 1567/4885MEN1 1747/4885 |
| US-20250026740-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | TNNI3, TNNT2, COQ8A | POLB 2974/4885EPHX2 3250/4885MEN1 3354/4885 |
| US-12122730-B2 | Methods of carbon-carbon bond fragmentation | CYCS, COX6C, COXFA4L2 | POLB 336/4885EPHX2 2377/4885MEN1 4097/4885 |
| US-20250026726-A1 | QUINAZOLINONE DIONE COMPOUNDS AND USES THEREOF | TNNI3, TNNT2, MYLK2 | POLB 3950/4885EPHX2 4284/4885MEN1 2683/4885 |
| US-12559464-B2 | Quinazolinone dione compounds and uses thereof | TNNI3, TNNT2, TNNC1 | POLB 2280/4885EPHX2 3856/4885MEN1 3559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.