Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA6 | P23280 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TPMT | P51580 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576605 | 0.82 | CA12 (0.62) | CA12CA1CA2CA4CA6 | |
| SCHEMBL917818 | 0.81 | MAPT (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL4576891 | 0.81 | CA12 (0.41) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11855711 | 0.78 | CYP3A4 (0.45) | CA12CA1CA2CA4CA6 | |
| SCHEMBL219096 | 0.78 | TUBB4A (0.55) | CYP3A4TSHRLMNATPMTKMT2A | |
| SCHEMBL28275397 | 0.78 | TUBB4A (0.55) | CYP3A4TSHRLMNATPMTKMT2A | |
| SCHEMBL987150 | 0.78 | LMNA (0.45) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11789059 | 0.78 | PKM (0.67) | CA12CA1CA2CA4CA6 | |
| SCHEMBL668639 | 0.78 | RXFP1 (0.56) | CA12CA1CA2CA4CA6 | |
| SCHEMBL4576407 | 0.77 | MAPK1 (0.39) | CA12CA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122029153-A | Aromatic hydrocarbon receptor modulator compound, and preparation method and application thereof | 德明药泰生物技术（深圳）有限公司 | 2026-05-12 | — | — | CN | disclosed |
| WO-2025082312-A1 | AROMATIC HYDROCARBON RECEPTOR MODULATOR COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 德明药泰生物技术（深圳）有限公司 | 2025-04-24 | — | — | WO | disclosed |
| WO-2025043084-A2 | METHODS OF PREPARING TAPINAROF AND RELATED COMPOUNDS | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2025-02-27 | — | — | WO | disclosed |
| CN-117447402-A | Aromatic hydrocarbon receptor modulator compound, and preparation method and application thereof | 德明药泰生物技术（深圳）有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-9051330-B2 | Dithiolopyrrolones with therapeutic activity | WELICHEM BIOTECH INC. (CA) | 2015-06-09 | — | — | US | disclosed |
| EP-2076519-B1 | NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS | CELESTIAL PHARMACEUTICALS SHENZHEN LTD (CN) | 2014-01-15 | — | — | EP | disclosed |
| US-8071637-B2 | Dithiolopyrrolones compounds and their therapeutic applications | WELICHEM BIOTECH INC. (CA) | 2011-12-06 | — | — | US | disclosed |
| EP-1490374-B1 | DITHIOLOPYRROLONE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES | WELICHEM BIOTECH INC (CA) | 2010-09-22 | — | — | EP | disclosed |
| US-20100041729-A1 | DITHIOLOPYRROLONES COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | CELESTIAL PHARMACEUTICALS (SHENZHEN) LTD. (CN) | 2010-02-18 | — | — | US | disclosed |
| EP-2076519-A2 | NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS | Celestial Pharmaceuticals (Shenzhen) LTD. (CN) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008038175-A2 | DITHIOLOPYRROLONES COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | CELESTIAL PHARMACEUTICALS (SHENZHEN) LTD. (CN) | 2008-04-03 | — | — | WO | disclosed |
| US-20060074125-A1 | Novel dithiolopyrrolones with therapeutic activity | WELICHEM BIOTECH INC. (CA) | 2006-04-06 | — | — | US | disclosed |
| EP-1490374-A2 | DITHIOLOPYRROLONE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES | Welichem Biotech Inc. (CA) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080624-A2 | DITHIOLOPYRROLONE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES | WELICHEM BIOTECH INC. (CA) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041729-A1 | DITHIOLOPYRROLONES COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | CD4, NDUFS3, TXN2 | CA12 2868/4885CA1 3067/4885CA2 2653/4885 |
| US-20060074125-A1 | Novel dithiolopyrrolones with therapeutic activity | TP53, DTYMK, MKI67 | CA12 3197/4885CA1 4079/4885CA2 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.