Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062416 | 0.75 | MAPT (0.39) | KDM1A | |
| SCHEMBL16526958 | 0.75 | ADRA2A (0.45) | — | |
| SCHEMBL16526952 | 0.72 | TSHR (0.48) | KDM1A | |
| SCHEMBL16526955 | 0.71 | ESR1 (0.31) | — | |
| SCHEMBL16976368 | 0.71 | RAPGEF4 (0.37) | — | |
| SCHEMBL2061978 | 0.68 | PNMT (0.53) | — | |
| SCHEMBL17656383 | 0.67 | OPRM1 (0.40) | — | |
| SCHEMBL17656375 | 0.67 | ESR2 (0.37) | — | |
| SCHEMBL12533714 | 0.65 | ASIC3 (0.44) | KDM1A | |
| SCHEMBL24335646 | 0.65 | BACE1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |