SCHEMBL29388809

SCHEMBL29388809

FC(F)(F)c1ccc(N2CCNCC2)nc1Cl

nearest known ligand 0.97

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.97
HTR3E A5X5Y0 3/20 0.51
HTR3B O95264 3/20 0.51
HTR3A P46098 3/20 0.51
HTR3D Q70Z44 3/20 0.51
HTR3C Q8WXA8 3/20 0.51
ALDH1A1 P00352 3/20 0.51
CYP1A2 P05177 4/20 0.51
CYP2C9 P11712 2/20 0.51
BPTF Q12830 1/20 0.49
ADRB1 P08588 3/20 0.47
EPHX2 P34913 1/20 0.47
HTR2C P28335 3/20 0.46
KDM4E B2RXH2 2/20 0.46
CYP3A4 P08684 2/20 0.46
HTR1A P08908 2/20 0.46
HSD17B10 Q99714 2/20 0.46
USP2 O75604 1/20 0.46
MAPK1 P28482 1/20 0.46
SLC6A4 P31645 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL906077 1.00 ADRB2 (0.97) ADRB2HTR3EHTR3BHTR3AHTR3D
Hydrochloric Acid SCHEMBL5585896 0.98 ADRB2 (1.00) ADRB2HTR3EHTR3BHTR3AHTR3D
Tert-Butyl Formate SCHEMBL27809039 0.87 ADRB2 (0.74) ADRB2HTR3EHTR3BHTR3AHTR3D
SCHEMBL23779626 0.84 ADRB2 (0.70) ADRB2ALDH1A1CYP1A2MAPK1HTT
SCHEMBL12780912 0.84 ADRB2 (0.70) ADRB2ALDH1A1CYP1A2MAPK1HTT
SCHEMBL12763838 0.81 ADRB2 (0.67) ADRB2CYP1A2LCATCXCR3
SCHEMBL5585596 0.80 ADRB2 (0.65) ADRB2ALDH1A1HTR2CLCATCXCR3
SCHEMBL5585785 0.80 ADRB2 (0.65) ADRB2ALDH1A1HTR2CLCATCXCR3
SCHEMBL5585598 0.80 ADRB2 (0.65) ADRB2ALDH1A1HTR2CLCATCXCR3
SCHEMBL25390151 0.80 ADRB2 (0.65) ADRB2CYP1A2CYP2C9CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250114351-A1 5-HT2C RECEPTOR MODULATING AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE, MENTAL, COGNITIVE AND AUTOIMMUNE CNS DISORDERS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2025-04-10 US claimed
WO-2023248222-A1 5-HT2C RECEPTOR MODULATING AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE, MENTAL, COGNITIVE AND AUTOIMMUNE CNS DISORDERS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2023-12-28 WO claimed
US-20220146492-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY SHINE IAN BASIL (US) 2022-05-12 US claimed
US-20250114351-A1 5-HT2C RECEPTOR MODULATING AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE, MENTAL, COGNITIVE AND AUTOIMMUNE CNS DISORDERS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2025-04-10 US disclosed
EP-4525833-A2 VETERINARY PHARMACEUTICAL FORMULATIONS Increvet, Inc. (US) 2025-03-26 EP disclosed
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FIRST WAVE BIO, INC. 2024-03-07 US disclosed
WO-2023248222-A1 5-HT2C RECEPTOR MODULATING AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE, MENTAL, COGNITIVE AND AUTOIMMUNE CNS DISORDERS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2023-12-28 WO disclosed
WO-2023225492-A2 VETERINARY PHARMACEUTICAL FORMULATIONS INCREVET, INC. (US) 2023-11-23 WO disclosed
WO-2023220930-A1 VETERINARY PHARMACEUTICAL FORMULATIONS CROSS-REFERENCES TO RELATED APPLICATIONS INCREVET, INC. (US) 2023-11-23 WO disclosed
US-20230372374-A1 VETERINARY PHARMACEUTICAL FORMULATIONS INCREVET, INC. 2023-11-23 US disclosed
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FIRST WAVE BIO, INC. (US) 2023-10-24 US disclosed
US-20230102999-A1 DEUTERATED NICLOSAMIDE FIRST WAVE BIO, INC. 2023-03-30 US disclosed
US-11564896-B2 Methods of treatment FIRST WAVE BIO, INC. (US) 2023-01-31 US disclosed
EP-4045480-A1 PHARMACEUTICAL FORMULATIONS First Wave Bio, Inc. (US) 2022-08-24 EP disclosed
US-20220249440-A1 MUSCLE REGENERATION PROMOTER SATO PHARMACEUTICAL CO., LTD. (JP) 2022-08-11 US disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220146492-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY SHINE IAN BASIL (US) 2022-05-12 US disclosed
US-20220105057-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2022-04-07 US disclosed
US-20220079897-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2022-03-17 US disclosed
EP-3953000-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY Shine, Ian Basil (US) 2022-02-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FH, CS, ECHS1 ADRB2 3795/4885HTR3E 1328/4885HTR3B 1701/4885
US-20220249440-A1 MUSCLE REGENERATION PROMOTER MUSK, MYLK2, MYH2 ADRB2 76/4885HTR3E 64/4885HTR3B 13/4885
US-20220079897-A1 METHODS OF TREATMENT ACE2, ACE, SI ADRB2 3018/4885HTR3E 1243/4885HTR3B 1651/4885
US-20230372374-A1 VETERINARY PHARMACEUTICAL FORMULATIONS SLC5A2, SLC5A1, SLC2A8 ADRB2 321/4885HTR3E 1434/4885HTR3B 1882/4885
US-11564896-B2 Methods of treatment ACE2, ACE, SI ADRB2 3495/4885HTR3E 1824/4885HTR3B 2079/4885
US-20220105057-A1 METHODS OF TREATMENT ACE2, ACE, SI ADRB2 3495/4885HTR3E 1824/4885HTR3B 2079/4885
US-20230102999-A1 DEUTERATED NICLOSAMIDE FH, IDH2, ECHS1 ADRB2 2922/4885HTR3E 1296/4885HTR3B 1479/4885
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FH, CS, ECHS1 ADRB2 3816/4885HTR3E 1317/4885HTR3B 1699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.