Tolonidine

Tolonidine

SCHEMBL29391908

Cc1ccc(NC2=NCCN2)c(Cl)c1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 12/20 0.55
ADRA2B P18089 11/20 0.55
ADRA2C P18825 11/20 0.55
ADRA1D P25100 9/20 0.55
ADRA1A P35348 9/20 0.55
ADRA1B P35368 9/20 0.55
TSHR P16473 1/20 0.54
NFKB1 P19838 1/20 0.54
HSD17B10 Q99714 1/20 0.54
CFB P00751 1/20 0.53
LMNA P02545 2/20 0.53
CYP2D6 P10635 2/20 0.53
NISCH Q9Y2I1 2/20 0.53
MEN1 O00255 1/20 0.53
SLC22A1 O15245 1/20 0.53
SLC22A3 O75751 1/20 0.53
HTR1A P08908 1/20 0.53
CYP2C9 P11712 1/20 0.53
HRH2 P25021 1/20 0.53
CYP2C19 P33261 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tolonidine SCHEMBL310600 1.00 ADRA2A (0.55) ADRA2AADRA2BADRA2CADRA1DADRA1A
Tolonidine SCHEMBL871225 0.90 ADRA2A (0.52) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL31442157 0.88 ADRA2A (0.64) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL29458121 0.84 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL11759345 0.84 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1DADRA1A
Moxonidine SCHEMBL28086339 0.82 ADRA2C (0.73) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL24658874 0.80 ADRA2A (0.71) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL11762970 0.79 ADRA2A (0.63) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL29349477 0.79 ADRA2A (0.63) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL9820148 0.78 ADRA2A (0.50) ADRA2AADRA2BADRA2CADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3359134-B1 COMPOSITIONS AND COMPOSITIONS FOR USE IN ON-DEMAND HIGH-EFFICIENCY TRIGGERABLE ANESTHESIA CHILDRENS MEDICAL CT CORP (US) 2025-04-09 EP claimed
US-12543749-B2 Starter strain and sourdough using the same LIVING JIN CO., LTD. (KR) 2026-02-10 US disclosed
CN-119152950-A Deep analysis method and application of microbiological ribosomal proteomics data set 河南科技大学第一附属医院 2024-12-17 CN disclosed
WO-2024197124-A2 ARGININE VASOPRESSIN RECEPTOR (AVPR) ANTAGONISTS AND METHODS OF USING THEREOF UNIVERSITY OF MIAMI (US) 2024-09-26 WO disclosed
US-20240148008-A1 Novel starter strain and sourdough using the same LIVING JIN CO., LTD. (KR) 2024-05-09 US disclosed
EP-4306637-A1 BACTERIOPHAGE(S) TARGETING CAPSULAR DEFICIENT KLEBSIELLA PNEUMONIAE (KP), COMPOSITIONS COMPRISING IT(THEM) AND USE(S) THEREOF INSTITUT PASTEUR (FR) 2024-01-17 EP disclosed
CN-117178189-A Method for detecting neurofilament light chains in plasma and cerebrospinal fluid 华盛顿大学 2023-12-05 CN disclosed
US-11773144-B2 Mosaic HIV-1 envelopes to induce ADCC responses DUKE UNIVERSITY (US) 2023-10-03 US disclosed
CN-114874657-B Functional additive suitable for double-component acrylic polyurethane varnish, and preparation method and application thereof 清远市浩宇化工科技有限公司 2023-06-16 CN disclosed
CN-114381436-B Klebsiella pneumoniae phage capable of producing ethanol at high yield and application thereof 首都儿科研究所 2023-06-02 CN disclosed
CN-114874657-A Functional additive suitable for double-component acrylic polyurethane varnish and preparation method and application thereof 清远市浩宇化工科技有限公司 2022-08-09 CN disclosed
CN-114106617-B Putty for vehicles and preparation method and application thereof 清远市浩宇化工科技有限公司 2022-05-10 CN disclosed
CN-114381436-A High-ethanol-yield Klebsiella pneumoniae phage and application thereof 首都儿科研究所 2022-04-22 CN disclosed
CN-114106617-A Putty for vehicles and preparation method and application thereof 清远市浩宇化工科技有限公司 2022-03-01 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12543749-B2 Starter strain and sourdough using the same MRPL38, FXR2, CHI3L2 ADRA2A 4639/4885ADRA2B 4584/4885ADRA2C 3594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.