Tolonidine

Tolonidine

SCHEMBL310600

Cc1ccc(NC2=NCCN2)c(Cl)c1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 12/20 0.55
ADRA2B P18089 11/20 0.55
ADRA2C P18825 11/20 0.55
ADRA1D P25100 9/20 0.55
ADRA1A P35348 9/20 0.55
ADRA1B P35368 9/20 0.55
TSHR P16473 1/20 0.54
NFKB1 P19838 1/20 0.54
HSD17B10 Q99714 1/20 0.54
CFB P00751 1/20 0.53
LMNA P02545 2/20 0.53
CYP2D6 P10635 2/20 0.53
NISCH Q9Y2I1 2/20 0.53
MEN1 O00255 1/20 0.53
SLC22A1 O15245 1/20 0.53
SLC22A3 O75751 1/20 0.53
HTR1A P08908 1/20 0.53
CYP2C9 P11712 1/20 0.53
HRH2 P25021 1/20 0.53
CYP2C19 P33261 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tolonidine SCHEMBL29391908 1.00 ADRA2A (0.55) ADRA2AADRA2BADRA2CADRA1DADRA1A
Tolonidine SCHEMBL871225 0.90 ADRA2A (0.52) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL31442157 0.88 ADRA2A (0.64) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL29458121 0.84 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL11759345 0.84 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1DADRA1A
Moxonidine SCHEMBL28086339 0.82 ADRA2C (0.73) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL24658874 0.80 ADRA2A (0.71) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL11762970 0.79 ADRA2A (0.63) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL29349477 0.79 ADRA2A (0.63) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL9820148 0.78 ADRA2A (0.50) ADRA2AADRA2BADRA2CADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 908 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250177354-A1 THERAPEUTIC COMBINATIONS, COMPOSITIONS, AND METHODS FOR DESIGNING AND PRODUCING ENTACTOGENIC MINDSTATES MINDSTATE DESIGN LABS INC (US) 2025-06-05 US claimed
WO-2025080559-A1 METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE ENALARE THERAPEUTICS INC. (US) 2025-04-17 WO claimed
US-20250114370-A1 METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE ENALARE THERAPEUTICS INC (US) 2025-04-10 US claimed
EP-3359134-B1 COMPOSITIONS AND COMPOSITIONS FOR USE IN ON-DEMAND HIGH-EFFICIENCY TRIGGERABLE ANESTHESIA CHILDRENS MEDICAL CT CORP (US) 2025-04-09 EP claimed
CN-119497589-A Therapeutic combinations, compositions and methods for designing and producing conditions that promote mental well-being 心境设计实验室股份有限公司 2025-02-21 CN claimed
US-20240139181-A1 METHODS FOR INDUCING PUPIL DILATION THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2024-05-02 US claimed
US-20230404979-A1 ALPHA-2 ADRENERGIC RECEPTOR AGONISTS TO REDUCE MORTALITY AND IMPROVE OUTCOMES IN VIRAL RESPIRATORY SYNDROMES RUSH UNIVERSITY MEDICAL CENTER (US) 2023-12-21 US claimed
WO-2023172701-A2 THERAPEUTIC COMBINATIONS, COMPOSITIONS, AND METHODS FOR DESIGNING AND PRODUCING ENTACTOGENIC MINDSTATES MINDSTATE DESIGN LABS, INC. (US) 2023-09-14 WO claimed
US-11738022-B2 Methods for inducing pupil dilation THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2023-08-29 US claimed
EP-4031000-A1 SYSTEMS AND METHODS FOR DETECTION AND PREVENTION OF EMERGENCE OF AGITATION Bioxcel Therapeutics, Inc. (US) 2022-07-27 EP claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
WO-2007056460-A2 TREATMENT OF LENGTH DEPENDENT NEUROPATHY ARCION THERAPEUTICS, INC. (US) 2007-05-18 WO claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0719139-A1 USE OF CENTRALLY ACTIVE ALPHAAGONISTS FOR INHIBING POSTRAUMATIC METABOLIC STRESS Dr. Karl Thomae GmbH (DE) 1996-07-03 EP claimed
WO-1995003798-A2 USE OF CENTRALLY EFFECTIVE α-2 AGONISTS FOR INHIBITING POSTAGGRESSION METABOLISM BOEHRINGER INGELHEIM INT (DE) 1995-02-09 WO claimed
EP-0573581-A4 COMPOSITIONS AND METHODS OF TREATMENT OF SYMPATHETICALLY MAINTAINED PAIN ARC 1 INC (US) 1994-06-29 EP claimed
EP-0573581-A1 COMPOSITIONS AND METHODS OF TREATMENT OF SYMPATHETICALLY MAINTAINED PAIN ARC 1, Inc. (US) 1993-12-15 EP claimed
WO-1992014453-A1 COMPOSITIONS AND METHODS OF TREATMENT OF SYMPATHETICALLY MAINTAINED PAIN ARC 1, INC. (US) 1992-09-03 WO claimed
US-4557934-A ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE THE PROCTER & GAMBLE COMPANY (US) 1985-12-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250177354-A1 THERAPEUTIC COMBINATIONS, COMPOSITIONS, AND METHODS FOR DESIGNING AND PRODUCING ENTACTOGENIC MINDSTATES CNR2, CNR1, HTR6 ADRA2A 629/4885ADRA2B 883/4885ADRA2C 334/4885
US-20250114370-A1 METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE ADRA2A, ADRA2C, OPRM1 ADRA2A 1/4885ADRA2B 6/4885ADRA2C 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.