Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532473 | 1.00 | MMP12 (0.54) | MMP12TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6682726 | 0.90 | NAAA (0.50) | MMP12TSHRSMN1; SMN2KMT2AHPGD | |
| SCHEMBL1836937 | 0.87 | TSHR (0.53) | MMP12TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29001222 | 0.87 | TSHR (0.53) | MMP12TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14690199 | 0.85 | MMP12 (0.50) | MMP12TSHRHTTHPGDALDH1A1 | |
| SCHEMBL10392265 | 0.84 | KMT2A (0.51) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL14685931 | 0.84 | PRKCG (0.47) | MMP12TSHRKMT2AMEN1HTT | |
| SCHEMBL7279889 | 0.84 | MMP12 (0.68) | MMP12TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL15949718 | 0.83 | TSHR (0.46) | MMP12TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5617244 | 0.83 | ALDH1A1 (0.52) | TSHRALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750135-B2 | Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-07-06 | — | — | US | disclosed |
| US-20080220487-A1 | Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols | THE BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY | 2008-09-11 | — | — | US | disclosed |
| WO-2008013949-A2 | MOLECULAR DESIGN OF THERMOSTABLE ALCOHOL DEHYDROGENASE FOR SYNTHESIS FOR CHIRAL AROMATIC ALCOHOLS | MICHIGAN STATE UNIVERSITY (US) | 2008-01-31 | — | — | WO | disclosed |
| US-7229817-B2 | Recombinant porcine liver esterases, their use and a method for the production thereof | DEGUSSA AG (DE) | 2007-06-12 | — | — | US | disclosed |
| EP-0872467-B1 | Process for the production of chiral unsaturated alcohols in high optical purity | EASTMAN CHEM CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-5886214-A | CATALYTIC ASYMMETRIC HYDROGENATION OF ENOL ESTERS BEARING A VINYLLIC OR AN ACETYLENIC SUBSTITUENT BY USING A CHIRAL RHODIUM(I) HYDROGENATION CATALYST PREPARED FROM A SUITABLE RHODIUM SALT AND AN OPTICALLY PURE PHOSPHINE LIGAND | EASTMAN CHEMICAL COMPANY (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0872467-A1 | Process for the production of chiral unsaturated alcohols in high optical purity | EASTMAN CHEMICAL COMPANY (US) | 1998-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080220487-A1 | Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols | ADH5, ADH1C, ADH1A | MMP12 3107/4885TSHR 1699/4885SMN1; SMN2 3285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.