Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 15/20 | 0.77 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24354820 | 0.87 | STING1 (1.00) | STING1RAPGEF3LMNAGMNNBLM | |
| SCHEMBL29884583 | 0.87 | STING1 (1.00) | STING1RAPGEF3LMNAGMNNBLM | |
| SCHEMBL20763201 | 0.87 | STING1 (0.77) | STING1 | |
| SCHEMBL23477313 | 0.87 | STING1 (1.00) | STING1RAPGEF3LMNAGMNNBLM | |
| SCHEMBL22216234 | 0.87 | STING1 (1.00) | STING1RAPGEF3LMNAGMNNBLM | |
| SCHEMBL24624852 | 0.84 | STING1 (0.73) | STING1RAPGEF3LMNAGMNNBLM | |
| SCHEMBL22571165 | 0.83 | STING1 (0.90) | STING1RAPGEF3LMNAGMNNBLM | |
| SCHEMBL24852827 | 0.82 | STING1 (0.69) | STING1RXFP1 | |
| SCHEMBL23798951 | 0.82 | STING1 (0.89) | STING1LMNA | |
| SCHEMBL24453568 | 0.80 | STING1 (0.84) | STING1RAPGEF3LMNAGMNNBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843903-B | Cyclic dinucleotide compounds | 勃林格殷格翰国际有限公司 | 2023-01-24 | — | — | CN | claimed |
| CN-110382515-B | Modified cyclic dinucleotide compounds | 勃林格殷格翰国际有限公司 | 2023-03-03 | — | — | CN | disclosed |
| CN-109843903-B | Cyclic dinucleotide compounds | 勃林格殷格翰国际有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-114306369-A | Thiooligonucleotide injection and preparation method thereof | 北京悦康科创医药科技股份有限公司 | 2022-04-12 | — | — | CN | disclosed |