Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943810 | 0.87 | THRA (0.44) | SIRT2F2RL3CA12CA1CA2 | |
| SCHEMBL2945759 | 0.87 | SIRT2 (0.39) | SIRT2F2RL3CA12CA1CA2 | |
| SCHEMBL2944827 | 0.87 | ENPP2 (0.48) | SIRT2PLA2G2AF2RL3CA12CA1 | |
| SCHEMBL2944855 | 0.85 | LMNA (0.41) | CHRM1F2RL3ALDH1A1MAPTLMNA | |
| SCHEMBL2951909 | 0.85 | F2RL3 (0.42) | SIRT2CHRM1PLA2G2AF2RL3CA12 | |
| SCHEMBL2945320 | 0.84 | PPARG (0.46) | F2RL3 | |
| SCHEMBL2948483 | 0.84 | ALDH1A1 (0.46) | ALDH1A1LMNAHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL2945245 | 0.83 | PTPN1 (0.38) | SIRT2HTR6F2RL3CA12CA1 | |
| SCHEMBL27925898 | 0.76 | MAPT (0.56) | SIRT2CHRM1F2RL3ALDH1A1MAPT | |
| SCHEMBL2949331 | 0.76 | TSHR (0.59) | ALDH1A1MAPTLMNATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754747-B2 | Oxazolo-naphthyl acids | WYETH LLC (US) | 2010-07-13 | — | — | US | disclosed |
| EP-1781645-A1 | OXAZOLO-NAPHTHYL ACIDS AS PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1(PAI-1) MODULATORS USEFUL IN THE TREATMENT OF THROMBOSIS AND CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20060052348-A1 | Oxazolo-naphthyl acids | WYETH (US) | 2006-03-09 | — | — | US | disclosed |
| WO-2006023865-A1 | OXAZOLO-NAPHTHYL ACIDS AS PLAMINOGEN ACTIVATOR INHIBTOR TYPE-1 (PAI-1) MODULATORS USEFUL IN THE TREATMENT OF THROMBOSIS AND CARDIOVASCULAR DISEASES | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052348-A1 | Oxazolo-naphthyl acids | SERPINE1, SERPINB1, SERPINC1 | SIRT2 1468/4885CHRM1 4613/4885HTR6 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.