Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.57 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.57 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.55 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibemethine SCHEMBL276863 | 0.85 | ALDH1A1 (0.70) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Dibemethine SCHEMBL10542007 | 0.85 | ALDH1A1 (0.70) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Dibemethine SCHEMBL2139708 | 0.82 | ALDH1A1 (0.67) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL3377392 | 0.82 | CARM1 (0.64) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL11278307 | 0.80 | ALDH1A1 (0.64) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL7055109 | 0.80 | CARM1 (0.75) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL11181366 | 0.79 | PYCR1 (0.57) | ALDH1A1TSHRLMNAMAOBPYCR1 | |
| SCHEMBL5234462 | 0.79 | SIGMAR1 (0.65) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL355111 | 0.78 | TSHR (0.61) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL22305213 | 0.78 | KDM4E (0.61) | ALDH1A1TSHRCARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 376 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103408554-A | Hypertensive activity reducing pyrrole coumarins compound and preparation method thereof | UNIV XI AN JIAOTONG | 2013-11-27 | — | — | CN | claimed |
| US-7846959-B2 | Raf modulators and methods of use | EXELIXIS, INC. (US) | 2010-12-07 | — | — | US | claimed |
| CN-101863941-A | Derivative of 3-oxygen-substituted 6,11-di-oxygen-clarithromycin A | UNIV WUHAN | 2010-10-20 | — | — | CN | claimed |
| CN-101845069-A | Derivative of 4'-substituted 6,11-2-oxygen-carithromycin A | UNIV WUHAN | 2010-09-29 | — | — | CN | claimed |
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| US-20080200693-A1 | Derivatives of Aryl (or Heteroaryl) Azolylcarbinols (in Particular Cizolirtin Citrate) for the Treatment of Opioid Addiction | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2008-08-21 | — | — | US | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| US-20080009488-A1 | Raf Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-01-10 | — | — | US | claimed |
| EP-1786420-A1 | DERIVATIVES OF ARYL (OR HETEROARYL) AZOLYLCARBINOLS FOR THE TREATMENT OF CENTRAL NEUROPATHIC PAIN | Laboratorios del Dr. Esteve S.A. (ES) | 2007-05-23 | — | — | EP | claimed |
| EP-0207674-A2 | 1,4-Dihydropyridine derivatives, their preparation and their pharmaceutical use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | claimed |
| EP-0189898-A1 | 1,6-Nephthyridinone derivatives and process for their preparation | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1986-08-06 | — | — | EP | claimed |
| EP-0180785-A1 | Pharmaceutical preparation containing a combination of Nitrendipin and Enalapril and process for its preparation | BAYER AG (DE) | 1986-05-14 | — | — | EP | claimed |
| EP-0063359-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES AND PROCESSES FOR PREPARING THE SAME | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1985-12-11 | — | — | EP | claimed |
| EP-0159040-A2 | Pyridine derivatives and production thereof | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1985-10-23 | — | — | EP | claimed |
| US-4535073-A | VASODILATION | NIPPON SHINYAKU CO LIMITED (JP) | 1985-08-13 | — | — | US | claimed |
| EP-0101023-A1 | Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1984-02-22 | — | — | EP | claimed |
| US-4404378-A | HYPOTENSIVE AGENTS; VASODILATION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1983-09-13 | — | — | US | claimed |
| EP-0063747-A1 | 2-Substituted or unsubstituted aminocarbonyloxyalkyl-1,4-dihydropyridines | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1982-11-03 | — | — | EP | claimed |
| EP-0063359-A1 | 1,4-Dihydropyridine derivatives and processes for preparing the same | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1982-10-27 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009488-A1 | Raf Modulators and Methods of Use | BRAF, RAF1, ARAF | ALDH1A1 2799/4885TSHR 3427/4885CARM1 1015/4885 |
| US-20080200693-A1 | Derivatives of Aryl (or Heteroaryl) Azolylcarbinols (in Particular Cizolirtin Citrate) for the Treatment of Opioid Addiction | CNR2, CNR1, HCRTR2 | ALDH1A1 451/4885TSHR 594/4885CARM1 1522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.