Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269009 | 0.87 | NPC1 (0.45) | MCHR1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2349832 | 0.83 | BCAT2 (0.47) | MCHR1BCAT2MAPTKDM4EALDH1A1 | |
| SCHEMBL31206831 | 0.83 | BCAT2 (0.47) | MCHR1BCAT2MAPTKDM4EALDH1A1 | |
| SCHEMBL30508584 | 0.82 | BCAT2 (0.43) | BCAT2ALDH1A1GAAMAPK1LMNA | |
| SCHEMBL28670188 | 0.80 | BCAT2 (0.44) | MCHR1BCAT2MAPT | |
| SCHEMBL18291611 | 0.79 | HTR7 (0.46) | BCAT2 | |
| SCHEMBL25318049 | 0.78 | NCF1 (0.41) | BCAT2 | |
| SCHEMBL4026841 | 0.78 | BCAT2 (0.40) | MCHR1BCAT2GAAMAPK1LMNA | |
| SCHEMBL4273729 | 0.76 | RAB9A (0.56) | MCHR1MAPTKDM4EALDH1A1TLR8 | |
| SCHEMBL6939611 | 0.76 | CHRNB2 (0.42) | MAPTKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759349-B2 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| CN-100582108-C | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING PLOUGH ANIMAL HEALTH | 2010-01-20 | — | — | CN | disclosed |
| EP-1699799-B1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF IMIDAZO [1,2-B]PYRIDAZINE DERIVATIVES | SCHERING PLOUGH LTD (CH) | 2007-05-16 | — | — | EP | disclosed |
| CN-1922181-A | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING PLOUGH ANIMAL HEALTH (CH) | 2007-02-28 | — | — | CN | disclosed |
| EP-1699799-A1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF IMIDAZO [1,2-B]PYRIDAZINE DERIVATIVES | Schering-Plough Ltd. (CH) | 2006-09-13 | — | — | EP | disclosed |
| US-20050182059-A1 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 2005-08-18 | — | — | US | disclosed |
| WO-2005066177-A1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES | SCHERING-PLOUGH LTD. (CH) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182059-A1 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | PLPBP, PIR, PPIP5K2 | MCHR1 909/4885BCAT2 2343/4885MAPT 4648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.