SCHEMBL29478461

SCHEMBL29478461

Cn1c(=O)c2c(ncn2CC(O)COC(=O)c2ccc(Cl)cc2Cl)n(C)c1=O

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 0.58
▸ SMN1; SMN2 Q16637 6/20 0.58
▸ RXFP1 Q9HBX9 5/20 0.57
▸ L3MBTL1 Q9Y468 2/20 0.57
▸ ALDH1A1 P00352 1/20 0.57
▸ POLB P06746 3/20 0.55
▸ MAPK1 P28482 1/20 0.50
▸ MAPT P10636 1/20 0.49
▸ KDM4E B2RXH2 1/20 0.49
▸ GAA P10253 1/20 0.49
▸ GLA P06280 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ UBE2N P61088 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10963455 0.80 LMNA (0.60) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
SCHEMBL10963461 0.78 LMNA (0.58) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
SCHEMBL10970100 0.77 LMNA (0.64) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
SCHEMBL682803 0.75 SMN1; SMN2 (0.57) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
SCHEMBL7010532 0.75 LMNA (0.69) LMNASMN1; SMN2RXFP1L3MBTL1POLB
SCHEMBL10967060 0.74 RXFP1 (0.54) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
SCHEMBL684353 0.73 SMN1; SMN2 (0.54) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
Dyphylline SCHEMBL123781 0.73 LMNA (1.00) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
Dyphylline SCHEMBL1816552 0.73 LMNA (1.00) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1
Dyphylline SCHEMBL8192 0.73 LMNA (1.00) LMNASMN1; SMN2RXFP1L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117028517-A Hydraulic-mechanical-electric composite transmission device 江苏大学 2023-11-10 — — CN claimed
EP-4233078-B1 NON-CURABLE SILICONE COMPOSITION COMPRISING CARBON BLACK MOMENTIVE PERFORMANCE MAT GMBH (DE) 2026-05-06 — — EP disclosed
EP-4684830-A2 SOLID EXTENDED-RELEASE COMPOSITION COMPRISING BRADYKININ B2-RECEPTOR ANTAGONISTS Pharvaris GmbH (CH) 2026-01-28 — — EP disclosed
EP-4499038-B1 SOLID COMPOSITION COMPRISING SOLUBILISED BRADYKININ B2-RECEPTOR ANTAGONISTS PHARVARIS GMBH (CH) 2025-12-03 — — EP disclosed
EP-4499039-B1 SOLID EXTENDED-RELEASE COMPOSITION COMPRISING BRADYKININ B2-RECEPTOR ANTAGONISTS PHARVARIS GMBH (CH) 2025-12-03 — — EP disclosed
EP-3850049-B2 FUNCTIONAL POLYSILOXANES MOMENTIVE PERFORMANCE MAT GMBH (DE) 2025-11-05 — — EP disclosed
US-12430472-B2 System for verifying edited image INVENTEC CORPORATION (TW) 2025-09-30 — — US disclosed
US-12421422-B2 Powder bed 3D printing process for producing elastic shaped body composed of silicones, and silicone resin-containing powder suitable for the process UNIVERSITÄT ROSTOCK (DE) 2025-09-23 — — US disclosed
US-20250268887-A1 THERAPEUTIC USES OF BRADYKININ B2-RECEPTOR ANTAGONISTS PHARVARIS GMBH (CH) 2025-08-28 — — US disclosed
US-20250228781-A1 SOLID COMPOSITION COMPRISING SOLUBILISED BRADYKININ B2-RECEPTOR ANTAGONISTS PHARVARIS GMBH (CH) 2025-07-17 — — US disclosed
EP-2879808-B1 PROCESS FOR THE MANUFACTURE OF A MULTILAYER SILICONE STRUCTURE MOMENTIVE PERFORMANCE MAT GMBH (DE) 2023-07-26 — — EP disclosed
US-11666582-B2 Medicament for treating cough NIPPON CHEMIPHAR CO., LTD. (JP) 2023-06-06 — — US disclosed
US-20230130902-A1 TEXT GENERATION APPARATUS, TEXT GENERATION LEARNING APPARATUS, TEXT GENERATION METHOD, TEXT GENERATION LEARNING METHOD AND PROGRAM NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 2023-04-27 — — US disclosed
CN-115752662-B Method and device for verifying consistency of magnetostrictive sensor 新创碳谷集团有限公司 2023-04-07 — — CN disclosed
EP-3850049-B1 FUNCTIONAL POLYSILOXANES MOMENTIVE PERFORMANCE MAT GMBH (DE) 2023-03-08 — — EP disclosed
CN-115752662-A Method and device for verifying consistency of magnetostrictive sensor 新创碳谷集团有限公司 2023-03-07 — — CN disclosed
US-20220380760-A1 DISRUPTING GENOMIC COMPLEX ASSEMBLY IN FUSION GENES FLAGSHIP PIONEERING INNOVATIONS V, INC. 2022-12-01 — — US disclosed
WO-2022207775-A1 PROCESS FOR CONTINUOUS HOT MELT GRANULATION OF LOW SOLUBLE PHARMACEUTICALS MERCK PATENT GMBH (DE) 2022-10-06 — — WO disclosed
US-11352377-B2 Process for the production of organohydridochlorosilanes MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2022-06-07 — — US disclosed
WO-2022084434-A1 NON-CURABLE SILICONE COMPOSITION COMPRISING CARBON BLACK MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) 2022-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11352377-B2 Process for the production of organohydridochlorosilanes DDT, PKD1, CDV3 LMNA 4470/4885SMN1; SMN2 3331/4885RXFP1 4452/4885
US-20250228781-A1 SOLID COMPOSITION COMPRISING SOLUBILISED BRADYKININ B2-RECEPTOR ANTAGONISTS BDKRB2, BDKRB1, BRS3 LMNA 2861/4885SMN1; SMN2 3197/4885RXFP1 83/4885
US-11666582-B2 Medicament for treating cough P2RX4, P2RX3, P2RX5 LMNA 2654/4885SMN1; SMN2 3808/4885RXFP1 408/4885
US-20250268887-A1 THERAPEUTIC USES OF BRADYKININ B2-RECEPTOR ANTAGONISTS BDKRB2, BDKRB1, BRS3 LMNA 1984/4885SMN1; SMN2 2758/4885RXFP1 153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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