SCHEMBL29486804

SCHEMBL29486804

CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 8/20 0.72
AGTR2 P50052 8/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7932871 0.84 AGTR1 (1.00) AGTR1AGTR2
SCHEMBL243579 0.81 AGTR1 (1.00) AGTR1AGTR2
SCHEMBL241232 0.80 AGTR1 (0.88) AGTR1AGTR2
SCHEMBL245015 0.79 AGTR1 (0.94) AGTR1AGTR2
SCHEMBL242315 0.78 AGTR1 (0.70) AGTR1AGTR2
SCHEMBL243624 0.78 AGTR1 (0.72) AGTR1AGTR2
SCHEMBL244082 0.78 AGTR1 (0.74) AGTR1AGTR2
SCHEMBL244173 0.78 AGTR1 (0.70) AGTR1AGTR2
SCHEMBL244413 0.78 AGTR1 (0.84) AGTR1AGTR2
SCHEMBL244676 0.78 AGTR1 (0.80) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3873904-B1 TETRAHYDROPYRAN (THP)-SUBSTITUTED BICYCLIC-PYRIMIDINEDIONE COMPOUNDS MYOKARDIA INC (US) 2024-07-10 EP claimed
US-20220340569-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES FOR TREATING CARDIAC DISEASES MYOKARDIA INC (US) 2022-10-27 US claimed
EP-4054588-A1 METHODS OF TREATMENT WITH MYOSIN MODULATOR MyoKardia, Inc. (US) 2022-09-14 EP claimed
CN-114945372-A Methods of treatment with myosin modulators 迈奥卡迪亚公司 2022-08-26 CN claimed
US-20220106314-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES FOR TREATING CARDIAC DISEASES MYOKARDIA INC (US) 2022-04-07 US claimed
EP-4736855-A2 TETRAHYDROPYRAN (THP)-SUBSTITUTED BICYCLIC-PYRIMIDINEDIONE COMPOUNDS MyoKardia, Inc. (US) 2026-05-06 EP disclosed
US-12616697-B2 Methods of treatment with myosin modulator MyoKardia, Inc. (US) 2026-05-05 US disclosed
EP-4464321-B1 TETRAHYDROPYRAN (THP)-SUBSTITUTED BICYCLIC-PYRIMIDINEDIONE COMPOUNDS MYOKARDIA INC (US) 2026-01-21 EP disclosed
US-20250339395-A1 COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND CATIONS NOVARTIS PHARMACEUTICALS CORP (US) 2025-11-06 US disclosed
US-20250325531-A1 TREATMENT OF SYSTOLIC DYSFUNCTION MyoKardia, Inc. (US) 2025-10-23 US disclosed
US-20250282779-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES FOR TREATING CARDIAC DISEASES MYOKARDIA INC (US) 2025-09-11 US disclosed
US-20250241903-A1 TREATMENT OF SYSTOLIC DYSFUNCTION MYOKARDIA INC (US) 2025-07-31 US disclosed
US-20220331282-A1 AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS NOVARTIS PHARMACECUTICALS CORPORATION 2022-10-20 US disclosed
EP-4054588-A1 METHODS OF TREATMENT WITH MYOSIN MODULATOR MyoKardia, Inc. (US) 2022-09-14 EP disclosed
CN-114945372-A Methods of treatment with myosin modulators 迈奥卡迪亚公司 2022-08-26 CN disclosed
US-20220265629-A1 TREATMENT OF SYSTOLIC DYSFUNCTION AND HEART FAILURE WITH REDUCED EJECTION FRACTION WITH THE COMPOUND (R)-4-(1-((3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)SULFONYL)-1-FLUOROETHYL)-N-(ISOXAZOL-3-YL)PIPERIDINE-1-CARBOXAMIDE MyoKardia, Inc. (US) 2022-08-25 US disclosed
US-20220257551-A1 AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS NOVARTIS PHARMACEUTICALS CORPORATION 2022-08-18 US disclosed
US-20220106314-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES FOR TREATING CARDIAC DISEASES MYOKARDIA INC (US) 2022-04-07 US disclosed
CN-114173782-A Treatment of cardiac contractile dysfunction and heart failure with reduced ejection fraction using the compound (R) -4- (1- ((3- (difluoromethyl) -1-methyl-1H-pyrazol-4-yl) sulfonyl) -1-fluoroethyl) -N- (isoxazol-3-yl) piperidine-1-carboxamide 迈奥卡迪亚公司 2022-03-11 CN disclosed
WO-2022047004-A1 METHODS OF TREATMENT WITH MYOSIN MODULATOR MyoKardia, Inc. (US) 2022-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282779-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES FOR TREATING CARDIAC DISEASES DHPS, THPO, TNNI3 AGTR1 1015/4885AGTR2 868/4885
US-20220106314-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES FOR TREATING CARDIAC DISEASES DHPS, THPO, TNNI3 AGTR1 1015/4885AGTR2 868/4885
US-20220340569-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES FOR TREATING CARDIAC DISEASES DHPS, THPO, TNNI3 AGTR1 1015/4885AGTR2 868/4885
US-20220331282-A1 AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS MME, DNPEP, AGTR1 AGTR1 3/4885AGTR2 5/4885
US-12616697-B2 Methods of treatment with myosin modulator MYH2, MYH14, MYH10 AGTR1 528/4885AGTR2 228/4885
US-20220257551-A1 AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS MME, DNPEP, AGTR1 AGTR1 3/4885AGTR2 5/4885
US-20220265629-A1 TREATMENT OF SYSTOLIC DYSFUNCTION AND HEART FAILURE WITH REDUCED EJECTION FRACTION WITH THE COMPOUND (R)-4-(1-((3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)SULFONYL)-1-FLUOROETHYL)-N-(ISOXAZOL-3-YL)PIPERIDINE-1-CARBOXAMIDE FABP3, TNNI3, TNNT2 AGTR1 116/4885AGTR2 158/4885
US-20250325531-A1 TREATMENT OF SYSTOLIC DYSFUNCTION FABP3, TNNI3, TNNT2 AGTR1 173/4885AGTR2 116/4885
US-20250339395-A1 COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND CATIONS MME, DNPEP, ANPEP AGTR1 8/4885AGTR2 9/4885
US-20250241903-A1 TREATMENT OF SYSTOLIC DYSFUNCTION FABP3, TNNI3, TNNT2 AGTR1 173/4885AGTR2 116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.