Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31315042 | 0.79 | PLK1 (0.76) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL24101354 | 0.79 | PLK1 (0.70) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL2775341 | 0.78 | LMNA (0.51) | KMT2ALMNA | |
| SCHEMBL10596017 | 0.75 | PLK1 (0.56) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL7558028 | 0.75 | CDC25B (0.69) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL29380721 | 0.74 | IDO1 (0.73) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL419307 | 0.74 | IDO1 (0.73) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL7842295 | 0.73 | PLK1 (0.67) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL4518755 | 0.73 | PLK1 (0.67) | PLK1HPGDSKMT2AHPGDCDC25B | |
| SCHEMBL4469856 | 0.73 | CDC25B (0.78) | PLK1HPGDSKMT2AHPGDCDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | AMBIT BIOSCIENCES CORPORATION | 2005-12-01 | — | — | US | disclosed |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-08 | — | — | US | disclosed |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-01 | — | — | US | disclosed |
| US-20050165031-A1 | Urea derivatives as ABL modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| US-20050165024-A1 | Urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165024-A1 | Urea derivatives as kinase modulators | ULK2, ULK1, ULK3 | PLK1 106/4885HPGDS 1465/4885KMT2A 1390/4885 |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | PLK1 1190/4885HPGDS 772/4885KMT2A 285/4885 |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | KIT, PRKCH, PRKCE | PLK1 928/4885HPGDS 1024/4885KMT2A 639/4885 |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | FLT4, FLT1, FLT3 | PLK1 371/4885HPGDS 760/4885KMT2A 1637/4885 |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | PDGFRA, PDGFRB, PDGFA | PLK1 730/4885HPGDS 92/4885KMT2A 2832/4885 |
| US-20050165031-A1 | Urea derivatives as ABL modulators | ABL1, ABL2, BCR | PLK1 1190/4885HPGDS 772/4885KMT2A 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.