Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.42 |
| ▸ | ILK | Q13418 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950165 | 0.89 | TLR7 (0.41) | TLR7ILKPTPN1CDK1CCNB1 | |
| SCHEMBL2953607 | 0.86 | TLR7 (0.44) | TLR7ILKPTPN1PIK3CACDK1 | |
| SCHEMBL2952316 | 0.82 | NPC1 (0.51) | — | |
| SCHEMBL2951937 | 0.82 | DHFR (0.45) | PIK3CACDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2946209 | 0.82 | TLR8 (0.37) | PTPN1CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2953257 | 0.73 | CDK1 (0.42) | TLR7CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2946049 | 0.73 | DHFR (0.42) | CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2951209 | 0.72 | KDM4E (0.42) | CDK1CCNB1CCNE1CDK2PIK3CD | |
| SCHEMBL2952950 | 0.71 | DHFR (0.43) | PIK3CAJAK2 | |
| SCHEMBL2955281 | 0.71 | CAMKK2 (0.45) | TLR7ILKPTPN1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |