Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952940 | 0.91 | SMPD3 (0.41) | INSRIGF1RALKFGFR1FGFR2 | |
| SCHEMBL2953119 | 0.86 | TTK (0.43) | INSRIGF1RALKEGFRFGFR1 | |
| SCHEMBL30399128 | 0.80 | FYN (0.41) | EGFRHSP90AA1HSP90AB1 | |
| SCHEMBL2954051 | 0.80 | DHFR (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL2952950 | 0.80 | DHFR (0.43) | INSRALKMEN1KMT2AHSP90AA1 | |
| SCHEMBL3034636 | 0.76 | HSP90AA1 (0.38) | INSRIGF1RALKHSP90AA1HSP90AB1 | |
| SCHEMBL2953676 | 0.74 | EGFR (0.39) | ALKEGFR | |
| SCHEMBL13177942 | 0.74 | L3MBTL1 (0.45) | INSRIGF1RALKCCR4MEN1 | |
| SCHEMBL2948890 | 0.74 | TTK (0.45) | INSRIGF1RALKHSP90AA1HSP90AB1 | |
| SCHEMBL2949173 | 0.73 | HSP90AA1 (0.47) | MEN1KMT2AHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |