Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.34 |
| ▸ | CTSS | P25774 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | VHL | P40337 | 1/20 | 0.30 |
| ▸ | ELOC | Q15369 | 1/20 | 0.30 |
| ▸ | ELOB | Q15370 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519878 | 0.76 | ARG1 (0.33) | — | |
| SCHEMBL6860632 | 0.76 | ARG1 (0.33) | — | |
| SCHEMBL16759709 | 0.69 | CHRM2 (0.31) | KMT2AMEN1MAPK1 | |
| SCHEMBL7286719 | 0.68 | ARG1 (0.42) | — | |
| SCHEMBL90052 | 0.67 | CA2 (0.50) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL83699 | 0.67 | CA2 (0.50) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL57432 | 0.67 | CA2 (0.50) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL6743171 | 0.67 | CTSK (0.43) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL20732867 | 0.65 | HDAC4 (0.48) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL28407302 | 0.65 | HDAC4 (0.48) | CTSKCTSSCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999182-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |