Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488466 | 0.96 | FUCA1 (0.60) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL20488123 | 0.94 | FUCA1 (0.58) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL21793950 | 0.92 | FUCA1 (0.56) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL5750271 | 0.92 | FUCA1 (0.56) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL21793953 | 0.92 | FUCA1 (0.56) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL25900100 | 0.91 | MC4R (0.55) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL6202706 | 0.91 | ACHE (0.56) | FUCA1SIGMAR1ACHECXCR3CYP1A2 | |
| SCHEMBL6742086 | 0.88 | FUCA1 (0.53) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL9271837 | 0.88 | FUCA1 (0.49) | FUCA1SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL6202941 | 0.87 | FUCA1 (0.60) | FUCA1SIGMAR1S1PR1S1PR5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41439-E1 | Pharmaceutical compositions and methods for use | TARGACEPT, INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1289996-B1 | HETEROARYLDIAZABICYCLOALKANES AS NICOTINIC CHOLINERGIC RECEPTOR LIGANDS | TARGACEPT INC (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1274710-B1 | NOVEL HETEROARYL-DIAZABICYCLOALKANES | NEUROSEARCH AS (DK) | 2005-02-23 | — | — | EP | disclosed |
| EP-1397365-B1 | HETEROARYL-DIAZABICYCLO-ALKANES AS CNS-MODULATORS | NEUROSEARCH AS (DK) | 2005-02-16 | — | — | EP | disclosed |
| US-6852721-B2 | Pharmaceutical compositions and methods for use | TARGACEPT, INC. (US) | 2005-02-08 | — | — | US | disclosed |
| US-20050004113-A1 | New bispidine compounds useful in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2005-01-06 | — | — | US | disclosed |
| US-20040229900-A1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | US | disclosed |
| US-6815438-B2 | CENTRAL NERVOUS SYSTEM DISORDERS | NEUROSEARCH A/S (DK) | 2004-11-09 | — | — | US | disclosed |
| US-20040147505-A1 | Novel heteroaryl-diazabicyclo alkanes as cns-modulators | NEUROSEARCH A/S (DK) | 2004-07-29 | — | — | US | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| WO-2001044243-A2 | NOVEL HETEROARYL-DIAZABICYCLOALKANES | NEUROSEARCH A/S (DK) | 2001-06-21 | — | — | WO | disclosed |
| WO-2000076998-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |
| WO-2000076999-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |
| US-5268481-A | Containing a benzene ring | BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECHANICAL COLLEGE ACTING FOR AND ON BEHALF OF OKLAHOMA STATE UNIVERSITY (US) | 1993-12-07 | — | — | US | disclosed |
| US-5043445-A | Bis-1,3-diazine heterocyclic derivatives as antiarrhythmic agents | OKLAHOMA STATE UNIVERSITY (US) | 1991-08-27 | — | — | US | disclosed |
| US-4980468-A | ANTIARRHYTHMIC AGENTS | BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECHANICAL COLLEGES ACTING FOR AND ON BEHALF OF OKLAHOMA STATE UNIVERSITY (US) | 1990-12-25 | — | — | US | disclosed |
| US-4910311-A | Containing a phenyl or thiophene ring | BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL MECHANICAL COLLEGES, ACTING FOR AND ON BEHALF OF OKLAHOMA STATE UNIV. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4778892-A | Certain 3-selena-7-aza-bicyclo[3.3.1]nonanes as antiarrhythmic agents | OKLAHOMA STATE UNIVERSITY (US) | 1988-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147505-A1 | Novel heteroaryl-diazabicyclo alkanes as cns-modulators | CHRNA3, CHRNA5, CHRNA2 | FUCA1 892/4885SIGMAR1 92/4885CHRM2 15/4885 |
| US-20040229900-A1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ADRA1B, ADRB2, ADRA1D | FUCA1 3693/4885SIGMAR1 211/4885CHRM2 164/4885 |
| US-20050004113-A1 | New bispidine compounds useful in the treatment of cardiac arrhythmias | DRD2, ADRA1D, KCND2 | FUCA1 4764/4885SIGMAR1 222/4885CHRM2 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.