Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL460575 | 1.00 | ALDH1A1 (0.40) | ALDH1A1GAASMN1; SMN2CYP3A4CYP1A2 | |
| Methacrylic Acid SCHEMBL8110276 | 0.85 | KDM4E (0.42) | ALDH1A1CYP2C9LMNAMAPTHPGD | |
| Methacrylic Acid SCHEMBL301490 | 0.85 | KDM4E (0.42) | ALDH1A1CYP2C9LMNAMAPTHPGD | |
| Acetone SCHEMBL11802482 | 0.84 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11175970 | 0.83 | TDP1 (0.50) | ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| Acrylic Acid SCHEMBL27650681 | 0.83 | ALDH1A1 (0.43) | ALDH1A1GAASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL3146710 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| Methacrylic Acid SCHEMBL3020182 | 0.82 | KDM4E (0.41) | ALDH1A1CYP2C9LMNAMAPTHPGD | |
| Acetamide SCHEMBL27724259 | 0.80 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| Styrene SCHEMBL1728767 | 0.80 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2CYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112672747-B | Peptides for activating cell signaling in osteoprogenitor cells | 加利福尼亚大学董事会 | 2025-02-18 | — | — | CN | disclosed |
| CN-118284413-A | Composition for localized bone formation | 奥斯菲治疗有限公司 | 2024-07-02 | — | — | CN | disclosed |
| US-20220160779-A1 | COMPOSITION FOR PROMOTING CARTILAGE TISSUE REGENERATION | NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) | 2022-05-26 | — | — | US | disclosed |