Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNA2 | P16389 | 2/20 | 0.43 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28111 | 0.79 | ALDH1A1 (0.60) | CYP3A4CYP1A1CYP1A2CYP1B1HPGD | |
| SCHEMBL602977 | 0.77 | KDM4E (0.62) | KDM4EPOLBABCB11ALDH1A1MAPK1 | |
| SCHEMBL30043104 | 0.77 | KDM4E (0.62) | KDM4EPOLBABCB11ALDH1A1MAPK1 | |
| SCHEMBL29368971 | 0.77 | KDM4E (0.62) | KDM4EPOLBABCB11ALDH1A1MAPK1 | |
| Isopimpinellin SCHEMBL498907 | 0.69 | CYP3A4 (1.00) | CYP3A4CYP1A1CYP1A2CYP1B1HPGD | |
| Isopimpinellin SCHEMBL29568822 | 0.69 | CYP3A4 (1.00) | CYP3A4CYP1A1CYP1A2CYP1B1HPGD | |
| SCHEMBL21297326 | 0.67 | ABCB11 (0.56) | KDM4EABCB11ALDH1A1MAPK1SMN1; SMN2 | |
| Lonapalene SCHEMBL120134 | 0.66 | ABCB11 (1.00) | CYP1A2HPGDKDM4EPOLBABCB11 | |
| SCHEMBL6008826 | 0.65 | ABCB11 (0.53) | ABCB11CYP2A6 | |
| Pimpinellin SCHEMBL2255899 | 0.65 | CYP3A4 (1.00) | CYP3A4CYP1A1CYP1A2CYP1B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153975-B | Novel naphthoquinones for use in the treatment of disease | Hangzhou Yier Biological Technology Co.,Ltd. (CN) | 2016-01-20 | — | — | CN | disclosed |
| US-8871802-B2 | Naphthoquinones for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2013-06-13 | — | — | US | disclosed |
| WO-2012024818-A1 | NOVEL ANPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | NQO1, NME2, CYP27B1 | CYP3A4 2063/4885CYP1A1 437/4885CYP1A2 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.