Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EDNRB | P24530 | 2/20 | 0.44 |
| ▸ | EDNRA | P25101 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265696 | 1.00 | PTGS2 (0.46) | PTGS2AKR1C3AKR1C2HSD17B2ATM | |
| SCHEMBL1887800 | 0.83 | TAAR1 (0.46) | PTGS2AKR1C3AKR1C2ALDH1A1MMP2 | |
| SCHEMBL10051059 | 0.83 | CA1 (0.55) | ALDH1A1 | |
| SCHEMBL18640198 | 0.83 | HSD17B2 (0.43) | PTGS2HSD17B2ATMALDH1A1MAPK1 | |
| SCHEMBL23913703 | 0.81 | ALDH1A1 (0.48) | HSD17B2ATMALDH1A1MAPK1EDNRB | |
| SCHEMBL3679487 | 0.81 | LMNA (0.54) | HSD17B2ATMALDH1A1EDNRBEDNRA | |
| SCHEMBL31668877 | 0.81 | LMNA (0.54) | HSD17B2ATMALDH1A1EDNRBEDNRA | |
| SCHEMBL31391247 | 0.81 | LMNA (0.54) | HSD17B2ATMALDH1A1EDNRBEDNRA | |
| SCHEMBL3035464 | 0.79 | ATM (0.46) | HSD17B2ATMALDH1A1MAPK1EDNRB | |
| SCHEMBL99072 | 0.78 | PSIP1 (0.56) | HSD17B2ATMALDH1A1MAPK1EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |
| CN-119137100-A | Process and intermediates for the preparation of pridopidine | 普瑞尼亚神经治疗有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-112778276-B | Compounds as SHP2 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-114980886-B | Compounds and methods for treating oxalate-related diseases | 奥沙鲁克斯公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-117651699-A | Compounds and compositions for the treatment of coronavirus related diseases | 诺华股份有限公司 | 2024-03-05 | — | — | CN | disclosed |
| CN-111170991-B | Antiproliferative compounds and methods of synthesis thereof | 细胞基因公司 | 2023-10-31 | — | — | CN | disclosed |
| EP-4263520-A1 | HETEROCYCLIC INHIBITORS OF PCSK9 | Cardio Therapeutics Pty Ltd (AU) | 2023-10-25 | — | — | EP | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
| EP-4168398-A1 | TYK-2 INHIBITOR | BeiGene, Ltd. (KY) | 2023-04-26 | — | — | EP | disclosed |
| CN-115715288-A | TYK-2 inhibitors | 百济神州有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-111471003-B | Preparation method of sitagliptin intermediate | 上海皓元医药股份有限公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-114980886-A | Compounds and methods for treating oxalate-related diseases | 奥沙鲁克斯公司 | 2022-08-30 | — | — | CN | disclosed |
| WO-2022133529-A1 | HETEROCYCLIC INHIBITORS OF PCSK9 | Cardio Therapeutics Pty Ltd (AU) | 2022-06-30 | — | — | WO | disclosed |
| EP-4017490-A1 | COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES | Oxalurx, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-111518002-B | Thioether compound, preparation method thereof, medical intermediate and application thereof | 南京林业大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-109153642-B | Indole and azaindole halogenated allylamine derivative inhibitors of lysyl oxidase and uses thereof | 法玛西斯有限公司 | 2022-05-17 | — | — | CN | disclosed |