Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Quercetin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 10/20 | 1.00 |
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.97 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 4/20 | 0.97 |
| ▸ | DPP4 known ✓ | P27487 | 3/20 | 0.97 |
| ▸ | FLT3 known ✓ | P36888 | 3/20 | 0.97 |
| ▸ | THRB known ✓ | P10828 | 3/20 | 0.97 |
| ▸ | SYK known ✓ | P43405 | 3/20 | 0.97 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 3/20 | 0.97 |
| ▸ | ALOX5 known ✓ | P09917 | 2/20 | 0.97 |
| ▸ | GSK3A known ✓ | P49840 | 2/20 | 0.97 |
| ▸ | GSK3B known ✓ | P49841 | 2/20 | 0.97 |
| ▸ | PIK3CG known ✓ | P48736 | 2/20 | 0.97 |
| ▸ | MMP1 known ✓ | P03956 | 2/20 | 0.97 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.97 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.97 |
| ▸ | MET known ✓ | P08581 | 1/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.97 |
| ▸ | CXCR1 known ✓ | P25024 | 1/20 | 0.97 |
| ▸ | PIK3R1 known ✓ | P27986 | 1/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quercetin SCHEMBL29695492 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL22103 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL29738299 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL28067078 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL1658852 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL29449339 | 0.99 | MEN1 (0.97) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL118425 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL29351036 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL19723 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| Quercetin SCHEMBL17629824 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351613-B2 | Production of glycoproteins using manganese | AMGEN INC. (US) | 2025-07-08 | — | — | US | disclosed |
| EP-4387642-B1 | HERBAL COMPOSITION FOR BREAST CANCER PREVENTION | MANN KEVEHAZI LAURA (GB) | 2025-02-19 | — | — | EP | disclosed |
| EP-4430174-A1 | PRODUCTION OF THERAPEUTIC PROTEINS | Amgen Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| EP-4387642-A1 | HERBAL COMPOSITION FOR BREAST CANCER PREVENTION | Mann Kevehazi, Laura (GB) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023117815-A1 | HERBAL COMPOSITION FOR BREAST CANCER PREVENTION | MANN KEVEHAZI LAURA (GB) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023086793-A1 | PRODUCTION OF THERAPEUTIC PROTEINS | AMGEN INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| EP-4155385-A1 | IMPROVED PRODUCTION OF GLYCOPROTEINS USING MANGANESE | Amgen Inc. (US) | 2023-03-29 | — | — | EP | disclosed |
| EP-1957630-B2 | IMPROVED PRODUCTION OF GLYCOPROTEINS USING MANGANESE | AMGEN INC (US) | 2023-03-29 | — | — | EP | disclosed |
| US-20220402986-A1 | PRODUCTION OF GLYCOPROTEINS USING MANGANESE | AMGEN INC. | 2022-12-22 | — | — | US | disclosed |
| CN-114555619-A | Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide | 麦德龙国际生物科技有限责任公司 | 2022-05-27 | — | — | CN | disclosed |