Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2959759 | 0.87 | LMNA (0.48) | ALDH1A1LMNAMAPTKDM4ENPSR1 | |
| SCHEMBL2959423 | 0.87 | LMNA (0.44) | ALDH1A1LMNAMAPTKDM4ENPSR1 | |
| SCHEMBL2958514 | 0.83 | LMNA (0.46) | ALDH1A1LMNAMAPTKDM4ENPSR1 | |
| SCHEMBL6819685 | 0.77 | KMT2A (0.57) | ALDH1A1LMNAMAPTKDM4ERAB9A | |
| SCHEMBL5634607 | 0.76 | GAA (0.44) | ALDH1A1LMNAMAPTKDM4ENPSR1 | |
| SCHEMBL7971386 | 0.75 | MAPK1 (0.49) | ALDH1A1LMNAMAPTKDM4ERAB9A | |
| SCHEMBL2951297 | 0.73 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTKDM4ENPSR1 | |
| SCHEMBL2953712 | 0.72 | POLB (0.45) | ALDH1A1LMNAMAPTKDM4ENPSR1 | |
| SCHEMBL7642311 | 0.72 | ALDH1A1 (0.39) | ALDH1A1LMNAMAPTKDM4ENPSR1 | |
| SCHEMBL2956627 | 0.72 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763643-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-07-27 | — | — | US | disclosed |
| US-20090137630-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-05-28 | — | — | US | disclosed |
| US-7488746-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-02-10 | — | — | US | disclosed |
| US-20080070947-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-20 | — | — | US | disclosed |
| US-7317033-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-01-08 | — | — | US | disclosed |
| CN-1324024-C | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | AVENTIS PHARMA GMBH (DE) | 2007-07-04 | — | — | CN | disclosed |
| US-20060160873-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-20 | — | — | US | disclosed |
| US-7049333-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-23 | — | — | US | disclosed |
| CN-1659163-A | Substituted thiophenes, process for their preparation, their use as medicaments or diagnostic reagents and medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2005-08-24 | — | — | CN | disclosed |
| US-20040006119-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137630-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | PLAT, CPS1, TST | ALDH1A1 429/4885LMNA 2455/4885MAPT 3886/4885 |
| US-20040006119-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | TST, GOT2, ALPP | ALDH1A1 386/4885LMNA 2192/4885MAPT 3261/4885 |
| US-20080070947-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | PLAT, TST, PNLIP | ALDH1A1 400/4885LMNA 1833/4885MAPT 3447/4885 |
| US-20060160873-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | PLAT, TST, PNLIP | ALDH1A1 400/4885LMNA 1833/4885MAPT 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.