SCHEMBL296280

SCHEMBL296280

CNCc1ccc(C(F)(F)F)cc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.55
SLC6A2 P23975 1/20 0.49
SLC6A4 P31645 1/20 0.49
SLC6A3 Q01959 1/20 0.49
TAAR1 Q96RJ0 1/20 0.48
LOXL2 Q9Y4K0 1/20 0.48
KDM4E B2RXH2 1/20 0.48
CYP3A4 P08684 1/20 0.48
MAPT P10636 1/20 0.48
IDO1 P14902 2/20 0.47
KIF11 P52732 1/20 0.47
KCNH2 Q12809 1/20 0.46
TMEM97 Q5BJF2 1/20 0.46
LSS P48449 1/20 0.46
MRGPRX4 Q96LA9 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
SCN8A Q9UQD0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL31186398 0.98 ALDH1A1 (0.53) ALDH1A1SLC6A2SLC6A4SLC6A3TAAR1
SCHEMBL2092499 0.94 KIF11 (0.57) ALDH1A1SLC6A2SLC6A4SLC6A3TAAR1
SCHEMBL30471981 0.85 ALDH1A1 (0.50) ALDH1A1TAAR1IDO1KCNH2TMEM97
SCHEMBL27180282 0.83 LOXL2 (0.45) ALDH1A1SLC6A2SLC6A4SLC6A3LOXL2
SCHEMBL1436108 0.81 PTPN1 (0.54) ALDH1A1TAAR1CYP3A4IDO1KCNH2
N-Benzylmethylamine SCHEMBL28250489 0.80 MAPT (0.49) ALDH1A1SLC6A2SLC6A4SLC6A3KDM4E
SCHEMBL13247118 0.80 LOXL2 (0.47) ALDH1A1SLC6A2SLC6A4SLC6A3LOXL2
SCHEMBL2504209 0.80 KDM4E (0.68) SLC6A2SLC6A4SLC6A3TAAR1LOXL2
SCHEMBL14048116 0.79 SCN8A (0.57) ALDH1A1KCNH2TMEM97SCN8A
Hydrochloric Acid SCHEMBL7347655 0.79 IDO1 (0.52) ALDH1A1TAAR1IDO1KCNH2TMEM97

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 288 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107827817-B Method for synthesizing formamide derivative through molybdenum catalytic formylation reaction 湘潭大学 2020-03-13 CN claimed
CN-107827816-B Method for synthesizing formamide derivative through graphene oxide catalytic formylation reaction 湘潭大学 2020-01-10 CN claimed
CN-107892670-B Method for synthesizing formamide derivative through cobalt-catalyzed formylation reaction 湘潭大学 2019-12-13 CN claimed
CN-105307651-A Thiazole compound and application thereof ABBVIE INC 2016-02-03 CN claimed
EP-2006271-A9 SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF Asahi Kasei Pharma Corporation (JP) 2009-07-29 EP claimed
US-20090054401-A1 Substituted bicyclic derivatives and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2009-02-26 US claimed
EP-2006271-A2 SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF Asahi Kasei Pharma Corporation (JP) 2008-12-24 EP claimed
EP-1519932-B1 BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY CYCLACEL LTD (GB) 2007-10-03 EP claimed
EP-4251624-B1 TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS AMGEN INC (US) 2025-10-29 EP disclosed
US-20240173307-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-05-30 US disclosed
US-20240101570-A1 TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS AMGEN INC. 2024-03-28 US disclosed
US-20240016775-A1 ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD (CN) 2024-01-18 US disclosed
CN-112204006-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-11-28 CN disclosed
US-11780843-B2 Compounds active towards nuclear receptors NUEVOLUTION A/S (DK) 2023-10-10 US disclosed
US-5389663-A Fungicides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-02-14 US disclosed
EP-0314422-B1 N-PHENYLALKYLBENZAMIDE FUNGICIDES DOWELANCO (US) 1993-07-28 EP disclosed
EP-0510700-A2 Azole compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-10-28 EP disclosed
US-4957533-A THIOAMIDES, AMIDINES ELI LILLY AND COMPANY (US) 1990-09-18 US disclosed
CN-1033797-A The N-phenylalkylbenzamidefungicides fungicides LILLY CO ELI (US) 1989-07-12 CN disclosed
EP-0314422-A2 N-phenylalkylbenzamide fungicides DOWELANCO (US) 1989-05-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054401-A1 Substituted bicyclic derivatives and use thereof LTB4R2, LTC4S, LTB4R ALDH1A1 1731/4885SLC6A2 3349/4885SLC6A4 2513/4885
US-11780843-B2 Compounds active towards nuclear receptors NCOA1, NR1H2, NCOA3 ALDH1A1 1638/4885SLC6A2 4262/4885SLC6A4 4193/4885
US-20240173307-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 ALDH1A1 3433/4885SLC6A2 2340/4885SLC6A4 2116/4885
US-20240016775-A1 ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR PARP3, PARP1, PARP4 ALDH1A1 1311/4885SLC6A2 4625/4885SLC6A4 2710/4885
US-20240101570-A1 TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS PRMT5, PRMT1, PRMT3 ALDH1A1 2101/4885SLC6A2 4841/4885SLC6A4 4761/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.