Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL486801 | 0.91 | HTR6 (0.46) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL777971 | 0.80 | MAPT (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL776895 | 0.78 | MAPT (0.55) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL31219737 | 0.78 | TSHR (0.45) | ALDH1A1MEN1KMT2AHTR6GAA | |
| SCHEMBL7541817 | 0.76 | HTR2A (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL20323435 | 0.75 | CA1 (0.36) | KDM4EKMT2AACHEMMP13CA12 | |
| SCHEMBL31219712 | 0.74 | ACHE (0.53) | MEN1KMT2AMAPTACHEGAA | |
| SCHEMBL15158160 | 0.73 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL24008845 | 0.72 | GAA (0.48) | ALDH1A1MEN1KMT2AMAPTACHE | |
| SCHEMBL17680474 | 0.72 | CA2 (0.45) | ALDH1A1GAAMMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971603-B1 | SULFOXIMINE DERIVATIVES AS p38 MAP KINASE INHIBITORS | CADILA HEALTHCARE LTD (IN) | 2012-03-14 | — | — | EP | disclosed |
| US-20100240709-A1 | Sulfoximine Derivatives as p38 MAP Kinase Inhibitors | CADILA HEALTHCARE LIMITED (IN) | 2010-09-23 | — | — | US | disclosed |
| EP-1971603-A2 | SULFOXIMINE DERIVATIVES AS p38 MAP KINASE INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007077574-A2 | SULFOXIMINE DERIVATIVES AS p38 MAP KINASE INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240709-A1 | Sulfoximine Derivatives as p38 MAP Kinase Inhibitors | MAPK1, MAP3K11, MAP3K1 | ALDH1A1 1807/4885KDM4E 4403/4885MEN1 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.