Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.66 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.66 |
| ▸ | PARP1 | P09874 | 20/20 | 0.74 |
| ▸ | TNKS | O95271 | 1/20 | 0.66 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.66 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.66 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.66 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.66 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.66 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.66 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.66 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.66 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.66 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.66 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.66 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.66 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.66 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19694846 | 0.92 | PARP1 (0.77) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL19705895 | 0.90 | PARP1 (0.74) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL18868376 | 0.88 | PARP1 (0.88) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL20386905 | 0.88 | PARP1 (0.78) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL9887628 | 0.88 | PARP1 (0.77) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL29722673 | 0.88 | PARP1 (0.77) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL24529039 | 0.87 | PARP1 (0.77) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL20386818 | 0.87 | PARP1 (0.77) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL29923010 | 0.87 | PARP1 (0.76) | PARP1TNKSADORA1CDK6PDE3A | |
| SCHEMBL29922994 | 0.87 | PARP1 (0.76) | PARP1TNKSADORA1CDK6PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11497757-B2 | Silanol based therapeutic payloads | BLINKBIO, INC. (US) | 2022-11-15 | — | — | US | disclosed |
| US-20220184104-A1 | SILANOL BASED THERAPEUTIC PAYLOADS | BLINKBIO INC (US) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11497757-B2 | Silanol based therapeutic payloads | CD47, CD4, BST2 | ADORA1 4566/4885PDE3A 4782/4885PARP1 2040/4885 |
| US-20220184104-A1 | SILANOL BASED THERAPEUTIC PAYLOADS | CD47, CD4, BST2 | ADORA1 4566/4885PDE3A 4782/4885PARP1 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.